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Article
Open AccessANKRD29, as a new prognostic and immunological biomarker of non–small cell lung cancer, inhibits cell growth and migration by regulating MAPK signaling pathway
The predominant cancer-related deaths worldwide are caused by lung cancer, particularly non-small cell lung cancer (NSCLC), despite the fact that numerous therapeutic initiatives have been devised to improve t...
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Article
Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation
Gliomas are the most aggressive primary brain tumors. However, no significant improvement in survival has been achieved with the addition of temozolomide (TMZ) or radiation as initial therapy, although many cl...
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Article
Open AccessMrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling
The incidence of cutaneous melanoma (CM) has been increasing annually worldwide. In this study, we identify that MrgprF, a MAS related GPR family member, is decreased in cutaneous melanoma tissues and cell lin...
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Article
Open AccessLncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway
Non-small cell lung cancer (NSCLC) is the most common type of human lung cancers, which has diverse pathological features. Although many signaling pathways and therapeutic targets have been defined to play imp...
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Article
A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau
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Article
Open AccessYTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved in various human cancers evolved rapidly in Tibetans and six Tibetan domestic mammals ...
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Article
Open AccessAuthor Correction: Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
In the original version of this Article, the affiliation details for Qiushuo Shen incorrectly omitted ‘Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650204, China’. This ...
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Article
Open AccessComprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
Recent genome-wide association studies (GWAS) have identified multiple risk loci that show strong associations with schizophrenia. However, pinpointing the potential causal genes at the reported loci remains a...
