16 Result(s)

Article

First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study

Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apati...

**aofeng Chen, Hao Xu, **aobing Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization

Fei Wang, Mei Jiang, Yongbin Chi, Gang Huang… in Molecular and Cellular Biochemistry (2024)

Article

Development and validation of a ¹⁸F-FDG PET/CT radiomics nomogram for predicting progression free survival in locally advanced cervical cancer: a retrospective multicenter study

The existing staging system cannot meet the needs of accurate survival prediction. Accurate survival prediction for locally advanced cervical cancer (LACC) patients who have undergone concurrent radiochemother...

Huiling Liu, Yongbin Cui, Cheng Chang, Zichun Zhou, Yalin Zhang… in BMC Cancer (2024)

Article

Untargeted serum metabolomics reveals potential biomarkers and metabolic pathways associated with the progression of gastroesophageal cancer

Previous metabolic studies in upper digestive cancer have mostly been limited to cross-sectional study designs, which hinders the ability to effectively predict outcomes in the early stage of cancer. This stud...

Jia**g Che, Yongbin Zhao, Bingbing Gu, Shuting Li, Yunfei Li, Keyu Pan… in BMC Cancer (2023)

Article

Machine learning models predict overall survival and progression free survival of non-surgical esophageal cancer patients with chemoradiotherapy based on CT image radiomics signatures

To construct machine learning models for predicting progression free survival (PFS) and overall survival (OS) with esophageal squamous cell carcinoma (ESCC) patients.

Yongbin Cui, Zhengjiang Li, Mingyue **ang, Dali Han, Yong Yin… in Radiation Oncology (2022)

Article

MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling

The incidence of cutaneous melanoma (CM) has been increasing annually worldwide. In this study, we identify that MrgprF, a MAS related GPR family member, is decreased in cutaneous melanoma tissues and cell lin...

Qiushuo Shen, Yanfei Han, Kai Wu, Yaomei He… in Signal Transduction and Targeted Therapy (2022)

Article

LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway

Non-small cell lung cancer (NSCLC) is the most common type of human lung cancers, which has diverse pathological features. Although many signaling pathways and therapeutic targets have been defined to play imp...

Yaomei He, **ulin Jiang, Lincan Duan, Qiuxia **ong, Yixiao Yuan… in Molecular Cancer (2021)

Article

A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma

Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose of this study was to explore the expression profiles of lipid metabolism-related genes (LMRG) in colorectal can...

Chao Yang, Shuoyang Huang, Fengyu Cao, Yongbin Zheng in BMC Cancer (2021)

Article

miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer

Qiuxia **ong, Li** Jiang, Kun Liu… in Signal Transduction and Targeted Therapy (2021)

Article

The role of m6A modification in the biological functions and diseases

N⁶-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m....

**ulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan… in Signal Transduction and Targeted Therapy (2021)

Article

First-generation EGFR tyrosine kinase inhibitor therapy in 106 patients with compound EGFR-mutated lung cancer: a single institution’s clinical practice experience

The antitumour efficacy of tyrosine kinase inhibitors (TKIs) in lung cancer patients with compound epidermal growth factor receptor (EGFR) mutations has not been resolved. Our study summarizes a single institutio...

**angyang Yu, Xuewen Zhang, Zichen Zhang, Yongbin Lin… in Cancer Communications (2018)

Article

Apoptosis, autophagy, necroptosis, and cancer metastasis

Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiog...

Zhenyi Su, Zuozhang Yang, Yongqing Xu, Yongbin Chen, Qiang Yu in Molecular Cancer (2015)

Article

Expression of MACC1 and c-Met in human gastric cancer and its clinical significance

Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role i...

Tiankang Guo, **gyu Yang, Jibin Yao, Yongbin Zhang, Mingxu Da… in Cancer Cell International (2013)

Article

Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation

We previously found that the low frequency magnetic fields (LF-MF) inhibited gastric and lung cancer cell growth. We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor. We here ...

Yunzhong Nie, Leilei Du, Yongbin Mou, Zhenjun Xu, Leihua Weng, Youwei Du… in BMC Cancer (2013)

Article

A specific miRNA signature promotes radioresistance of human cervical cancer cells

The mechanisms responsible for cervical cancer radioresistance are still largely unexplored. The present study aimed to identify miRNAs associated with radioresistance of cervical cancer cells.

Bin Zhang, Jun Chen, Zhenghua Ren, Yongbin Chen, **hui Li… in Cancer Cell International (2013)

Article

Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expression

NDRG2, a member of N-Myc downstream regulated gene family, plays some roles in cellular stress, cell differentiation and tumor suppression. We have found that NDRG2 expression in cervical cancer Hela cells inc...

Junye Liu, Le Yang, Jian Zhang, **g Zhang, Yongbin Chen, Kangchu Li… in BMC Cancer (2012)