6 Result(s)

Article

First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study

Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apati...

**aofeng Chen, Hao Xu, **aobing Chen… in Signal Transduction and Targeted Therapy (2024)

Article

MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling

The incidence of cutaneous melanoma (CM) has been increasing annually worldwide. In this study, we identify that MrgprF, a MAS related GPR family member, is decreased in cutaneous melanoma tissues and cell lin...

Qiushuo Shen, Yanfei Han, Kai Wu, Yaomei He… in Signal Transduction and Targeted Therapy (2022)

Article

miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer

Qiuxia **ong, Li** Jiang, Kun Liu… in Signal Transduction and Targeted Therapy (2021)

Article

The role of m6A modification in the biological functions and diseases

N⁶-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m....

**ulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan… in Signal Transduction and Targeted Therapy (2021)

Article

Expression of MACC1 and c-Met in human gastric cancer and its clinical significance

Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role i...

Tiankang Guo, **gyu Yang, Jibin Yao, Yongbin Zhang, Mingxu Da… in Cancer Cell International (2013)

Article

A specific miRNA signature promotes radioresistance of human cervical cancer cells

The mechanisms responsible for cervical cancer radioresistance are still largely unexplored. The present study aimed to identify miRNAs associated with radioresistance of cervical cancer cells.

Bin Zhang, Jun Chen, Zhenghua Ren, Yongbin Chen, **hui Li… in Cancer Cell International (2013)