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Open AccessStructural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). ...
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Open AccessThe middle lipin domain adopts a membrane-binding dimeric protein fold
Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular membranes. Using hydrogen d...
