-
Article
miR-212 and miR-132 are dispensable for mouse mammary gland development
-
Article
Open AccessEpigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection
Persistent colonization of the gastric mucosa by Helicobacter pylori (Hp) elicits chronic inflammation and aberrant epithelial cell proliferation, which increases the risk of gastric cancer. Here we examine the a...
-
Article
Open AccessLate-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation
Autosomal recessive cerebellar ataxias and autosomal recessive hereditary spastic paraplegias (ARHSPs) are clinically and genetically heterogeneous neurological disorders. Herein we describe Japanese siblings ...
-
Article
Open AccessGenome-wide compendium and functional assessment of in vivo heart enhancers
Whole-genome sequencing is identifying growing numbers of non-coding variants in human disease studies, but the lack of accurate functional annotations prevents their interpretation. We describe the genome-wid...
-
Article
Enhancer redundancy provides phenotypic robustness in mammalian development
Gene enhancer knockout phenotypes and analysis of enhancer activity patterns show that developmental genes are regulated by multiple redundant enhancers in mouse embryos.
-
Article
Open AccessAn atlas of dynamic chromatin landscapes in mouse fetal development
The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental stages from 10.5 days after concept...
-
Article
Supervised enhancer prediction with epigenetic pattern recognition and targeted validation
Enhancers are important non-coding elements, but they have traditionally been hard to characterize experimentally. The development of massively parallel assays allows the characterization of large numbers of e...
-
Article
Open AccessAuthor Correction: An atlas of dynamic chromatin landscapes in mouse fetal development
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessAuthor Correction: An atlas of dynamic chromatin landscapes in mouse fetal development
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03089-4.
-
Article
Open AccessTopologically associating domain boundaries are required for normal genome function
Topologically associating domain (TAD) boundaries partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and caus...
-
Article
Open AccessDynamic enhancer landscapes in human craniofacial development
The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during c...
