-
Article
Open AccessLoss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis
DDHD2/KIAA0725p is a mammalian intracellular phospholipase A1 that exhibits phospholipase and lipase activities. Mutation of the DDHD2 gene causes hereditary spastic paraplegia (SPG54), an inherited neurological ...
-
Article
Open AccessThe NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex
Abl interactor (Abi) family proteins play significant roles in actin cytoskeleton organization through participation in the WAVE complex. Mammals possess three Abi proteins: Abi-1, Abi-2, and NESH/Abi-3. Abi-1...
-
Article
Open AccessLate-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation
Autosomal recessive cerebellar ataxias and autosomal recessive hereditary spastic paraplegias (ARHSPs) are clinically and genetically heterogeneous neurological disorders. Herein we describe Japanese siblings ...
-
Chapter
The Structures and Functions of Intracellular Phospholipase A1 Family Proteins
Phospholipase A1 is an enzyme that hydrolyzes phospholipids, producing 2-acyl-lysophospholipids and fatty acids. Intracellular phospholipase A1 (iPLA1) functions inside cells. Except for a short lipase consensus ...
-
Article
A lysophospholipid acyltransferase antagonist, CI-976, creates novel membrane tubules marked by intracellular phospholipase A1 KIAA0725p
CI-976 is a lysophospholipid acyltransferase antagonist that is known to affect secretory and endocytic membrane-trafficking pathways likely by increasing the lysophospholipid content in membranes. Our previou...
