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Article
Open AccessStrong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals
Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor for suicidality. Recent evidence shows that accelerated cellular senescence/aging is associated with psychiatric il...
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Chapter
Genomics in Treatment Development
The Human Genome Project mapped the 3 billion base pairs in the human genome, which ushered in a new generation of genomically focused treatment development. While this has been very successful in other areas,...
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Article
Open AccessDissecting early life stress-induced adolescent depression through epigenomic approach
Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression thro...
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Article
Open AccessCorticosterone-mediated regulation and functions of miR-218-5p in rat brain
Chronic stress is one of the key precipitating factors in major depressive disorder (MDD). Stress associated studies have underscored the mechanistic role of epigenetic master players like microRNAs (miRNAs) i...
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Protocol
The Role of Transcriptional Profiling in Neurobiology and Treatment of Major Depression: A Translational Perspective on RNA Sequencing Platform
High-throughput transcriptomic profiling is a powerful experimental strategy to understand complex neurobiological mechanisms associated with many disorders, including major depressive disorder (MDD). Arguably...
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Article
Open AccessEarly life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in rats
The hypothalamus plays a key role in the stress response. While early life stress (ELS) increases susceptibility to psychiatric disorders including major depressive disorder (MDD), acute stress during adulthoo...
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Article
Open AccessDifferential and unique patterns of synaptic miRNA expression in dorsolateral prefrontal cortex of depressed subjects
Altered synaptic plasticity is often associated with major depressive disorder (MDD). Disease-associated changes in synaptic functions are tightly correlated with altered microRNA (miRNA) expression. Here, we ...
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Article
Open AccessMolecular pathology associated with altered synaptic transcriptome in the dorsolateral prefrontal cortex of depressed subjects
Disrupted synaptic plasticity is the hallmark of major depressive disorder (MDD), with accompanying changes at the molecular and cellular levels. Often, the maladaptive molecular changes at the synapse are the...
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Article
Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders
Non-invasive peripheral biomarkers play a significant role in both disease diagnosis and progression. In the past few years, microRNA (miRNA) expression changes in circulating peripheral tissues have been foun...
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Article
The Search for Smartness in Working, Living and Organising: Beyond the ‘Technomagic’
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Article
Open AccessMicroRNA mediators of early life stress vulnerability to depression and suicidal behavior
Childhood environment can have a profound impact on brain structure and function. Epigenetic mechanisms have been shown to play a critical role in adaptive and maladaptive processes by regulating gene expressi...
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Chapter and Conference Paper
Visualising the Knowledge Domain of Artificial Intelligence in Marketing: A Bibliometric Analysis
As the number of research outputs in the field of AI in Marketing increased greatly in the past 20 years, a systematic review of the literature and its developmental process is essential to provide a consolida...
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Chapter and Conference Paper
Unanticipated Consequences of Interactive Marketing: Systematic Literature Review and Directions for Future Research
Internet and social media have created new opportunities and challenges for marketing practices. This research provides a comprehensive analysis of the unanticipated consequences of interactive marketing. The...
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Chapter and Conference Paper
A Review and Weight Analysis of Factors Affecting Helpfulness of Electronic Word-of-Mouth Communications
eWOM communications significantly affect consumer behaviour. Previous studies found that helpful online reviews affect information adoption, which results in intention to buy. As a result, large number of stud...
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Article
A Novel Animal Model for Studying Depression Featuring the Induction of the Unfolded Protein Response in Hippocampus
Depression is the leading cause of disability worldwide with global distribution of 322 million people suffering from the disease. While much is understood about depression, the underlying pathophysiology is y...
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Article
Open AccessLinking unfolded protein response to inflammation and depression: potential pathologic and therapeutic implications
Depression is a devastating mental disorder that affects millions of people worldwide. Inflammation has been shown to be a key factor involved in the underlying pathophysiology of depression and has been shown...
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Article
Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain
Testosterone is an anabolic androgenic steroid hormone involved in brain development, reproduction, and social behavior. Several studies have shown that testosterone can cause impulsivity in humans, which in t...
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Article
Open AccessBalancing Digital-By-Default with Inclusion: A Study of the Factors Influencing E-Inclusion in the UK
Digital inclusion research has been critically important in drawing an understanding of how policies, society, organisations, and information technologies can all come together within a national environment th...
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Article
Open AccessCo-expression network modeling identifies key long non-coding RNA and mRNA modules in altering molecular phenotype to develop stress-induced depression in rats
Long non-coding RNAs (lncRNAs) have recently emerged as one of the critical epigenetic controllers, which participate in several biological functions by regulating gene transcription, mRNA splicing, protein in...
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Article
Role of HPA and the HPG Axis Interaction in Testosterone-Mediated Learned Helpless Behavior
Affective disorders show sex-specific differences in prevalence, symptoms, and complications. One hypothesis for this discrepancy is the interaction between the hypothalamic-pituitary-adrenal (HPA) axis and hy...
