7 Result(s)
within
Yiqiao Hu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessChiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination
Radiation-induced in situ tumor vaccination alone is very weak and insufficient to elicit robust antitumor immune responses. In this work, we address this issue by develo** chiral vidarabine monophosphate-ga...
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Article
Open AccessNLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis
The PI3K/AKT pathway plays an essential role in tumour development. NOD-like receptors (NLRs) regulate innate immunity and are implicated in cancer, but whether they are involved in PI3K/AKT pathway regulation...
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Article
Open AccessNanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress
Radiation therapy can potentially induce immunogenic cell death, thereby priming anti-tumor adaptive immune responses. However, radiation-induced systemic immune responses are very rare and insufficient to mee...
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Article
Open AccessPerfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
Hypoxia-based agents (HBAs), such as anaerobic bacteria and bioreductive prodrugs, require both a permeable and hypoxic intratumoural environment to be fully effective. To solve this problem, herein, we report...
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Article
Open AccessGenome-wide copy number variation analysis in a Chinese autism spectrum disorder cohort
Autism spectrum disorder (ASD) describes a group of neurodevelopmental disorders with high heritability, although the underlying genetic determinants of ASDs remain largely unknown. Large-scale whole-genome st...
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Article
Open AccessSelf-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy
Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths. ...
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Article
Open AccessPerfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy
Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet oxygen (1O2) using a photosensitizer. However, pre-existing hypoxia in tumours and oxygen consumption during PDT can...
