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Article
BDNF-VGF Pathway Aggravates Incision Induced Acute Postoperative Pain via Upregulating the Neuroinflammation in Dorsal Root Ganglia
Approximately one-third of postoperative patients are troubled by postoperative pain. Effective treatments are still lacking. The aim of this study is to investigate the role of brain-derived neurotrophic fact...
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Article
Open AccessChiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination
Radiation-induced in situ tumor vaccination alone is very weak and insufficient to elicit robust antitumor immune responses. In this work, we address this issue by develo** chiral vidarabine monophosphate-ga...
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Article
Open AccessPD-L1/PD-1 pathway: a potential neuroimmune target for pain relief
Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug treatment, as the main method to relieve pain at present, is often accompanied by different degrees of adverse reactions. ...
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Article
STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats
The purpose of this study was to study the effect of STING-IFN-I pathway on incision induced postoperative pain in rats and its possible mechanisms.
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Article
The 2011 Collaborative Innovation Plan, University-Industry Collaboration and Achievement Transformation of Universities: Evidence from China
Achievement transformation combines science and technology with the economy effectively. Governments from different countries have formulated lots of policies in order to foster university-industry collaborati...
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Article
Electroacupuncture Alleviates CFA-Induced Inflammatory Pain via PD-L1/PD-1-SHP-1 Pathway
Inflammatory pain is difficult to treat clinically, but electroacupuncture (EA) has been demonstrated to be effective in alleviating inflammatory pain. Programmed cell death ligand-1 (PD-L1) and its downstream...
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Article
Open AccessProcedural analgesic interventions in China: a national survey of 2198 hospitals
Humane treatment requires the provision of appropriate sedation and analgesia during medical diagnosis and treatment. However, limited information is available about the status of procedural analgesic interven...
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Article
Open AccessThe role of anesthesiologists’ perceived self-efficacy in anesthesia-related adverse events
Self-efficacy, as the vital determinant of behavior, influencing clinicians’ situation awareness, work performance, and medical decision-making, might affect the incidence of anesthesia-related adverse events ...
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Article
Myosin light chain 2 marks differentiating ventricular cardiomyocytes derived from human embryonic stem cells
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great value for studies of human cardiac development, drug discovery, disease modeling, and cell therapy. However, the mixed cardiomyocyte sub...
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Article
Open AccessThe role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review
Extracorporeal life support treatments such as extracorporeal membrane oxygenation (ECMO) have been recommended for the treatment of severe acute respiratory distress syndrome (ARDS) patients with coronavirus ...
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Article
Protectin DX ameliorates inflammation in sepsis-induced acute lung injury through mediating PPARγ/NF-κB pathway
Previous reports have demonstrated that the newly identified lipid mediator protectin DX (PDX) could effectively attenuate multiple organ injuries in sepsis. The aim of our study was to clarify whether PDX cou...
