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Article
Open AccessConstructing and implementing a performance evaluation indicator set for artificial intelligence decision support systems in pediatric outpatient clinics: an observational study
Artificial intelligence (AI) decision support systems in pediatric healthcare have a complex application background. As an AI decision support system (AI-DSS) can be costly, once applied, it is crucial to focu...
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Article
Use of Seamless Study Designs in Oncology Clinical Development– A Survey Conducted by IDSWG Oncology Sub-team
Seamless study designs have the potential to accelerate clinical development. The use of innovative seamless designs has been increasing in the oncology area; however, while the concept of seamless designs bec...
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Article
Variance component adaptive estimation algorithm for coseismic slip distribution inversion using interferometric synthetic aperture radar data
When conducting coseismic slip distribution inversion with interferometric synthetic aperture radar (InSAR) data, there is no universal method to objectively determine the appropriate size of InSAR data. Curre...
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Article
Open AccessPrevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury
The gut microbiota plays a critical role in regulating brain function through the microbiome-gut-brain axis (MGBA). Dysbiosis of the gut microbiota is associated with neurological impairment in Traumatic brain...
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Article
A systematic knowledge pedigree analysis on green governance
As the importance of green governance (GG) for achieving sustainable development is generally recognized, research in this field is booming and has interdisciplinary features. Given of that, a systematic knowl...
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Article
Open AccessKAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m6A reader YTHDC1 protein degradation
Neuroblastoma (NB) patients with amplified MYCN often face a grim prognosis and are resistant to existing therapies, yet MYCN protein is considered undruggable. KAP1 (also named TRIM28) plays a crucial role in...
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Article
Open AccessMechanically strained osteocyte-derived exosomes contained miR-3110-5p and miR-3058-3p and promoted osteoblastic differentiation
Osteocytes are critical mechanosensory cells in bone, and mechanically stimulated osteocytes produce exosomes that can induce osteogenesis. MicroRNAs (miRNAs) are important constituents of exosomes, and some m...
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Article
Open AccessPopulation genetic analyses highlight an eastward dispersal of Puccinia striiformis f. sp. tritici from the Shaanxi province to the North China Plain
Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a common airborne wheat disease. The frequent occurrence at a large scale in China has caused significant yield losses and poses a consid...
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Article
Open AccessLINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
Cancer stem-like cell is a key barrier for therapeutic resistance and metastasis in various cancers, including breast cancer, yet the underlying mechanisms are still elusive. Through a genome-wide lncRNA expre...
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Article
Remote Ischemic Post-conditioning Reduces Cognitive Impairment in Rats Following Subarachnoid Hemorrhage: Possible Involvement in STAT3/STAT5 Phosphorylation and Th17/Treg Cell Homeostasis
The inflammatory response following subarachnoid hemorrhage (SAH) may lead to Early Brain Injury and subsequently contribute to poor prognosis such as cognitive impairment in patients. Currently, there is a la...
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Protocol
Quantitation of Active Pharmaceutical Ingredients in Polymeric Drug Products Using Elemental Analysis
Polymeric prodrugs have gained significant popularity as a strategy to enhance the bioavailability and improve the pharmacokinetic properties of active pharmaceutical ingredients (API). Since the amount of the...
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Chapter and Conference Paper
Pore Scale Dynamic 3D Imaging of Water-Alternating-Gas Flooding and CO2-foam Flooding in a Double Layer Core
The geological carbon dioxide storage is usually combined with the enhanced oil recovery. The reservoir heterogeneity (such as bedding) often leads to reduced volumetric sweep efficiency in sandstone. To study...
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Chapter and Conference Paper
Advancements and Applications of Building-Integrated Photovoltaics (BIPV) in China
Power generation in buildings plays an important role in promoting carbon neutrality in the building sector. Building-Integrated Photovoltaic (BIPV) could provide energy (electricity) to buildings and thus dec...
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Chapter and Conference Paper
Enhancing Open-Set Object Detection via Uncertainty-Boxes Identification
Open-set object detection is a challenging task in computer vision, which aims to detect known object categories while simultaneously identifying unknown objects. Inspired by how humans naturally distinguish u...
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Article
Open AccessA novel 268 kb deletion combined with a splicing variant in IL7R causes of severe combined immunodeficiency in a Chinese family: a case report
Severe combined immunodeficiency (SCID) is a group of fatal primary immunodeficiencies characterized by the severe impairment of T-cell differentiation. IL7R deficiency is a rare form of SCID that usually present...
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Article
Correction: Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity
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Article
Enhancing lead adsorption capacity prediction in biochar: a comparative study of machine learning models and parameter optimization
Machine learning models for predicting lead adsorption in biochar, based on preparation features, are currently lacking in the environmental field. Existing conventional models suffer from accuracy limitations...
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Article
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
High-risk neuroblastoma (NB) still has an unfavorable prognosis and inducing NB differentiation is a potential strategy in clinical treatment, yet underlying mechanisms are still elusive. Here we identify TRIM...
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Article
Open AccessHealth effects and externalities of the popularization of sanitary toilets: evidence from Rural China
This study aimed to assess the impact of the increased prevalence of sanitary toilets in rural areas on the health of rural residents, and whether the popularity thereof has a positive externality. This study ...
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Article
Inhibition of GPR17/ID2 Axis Improve Remyelination and Cognitive Recovery after SAH by Mediating OPC Differentiation in Rat Model
Myelin sheath injury contributes to cognitive deficits following subarachnoid hemorrhage (SAH). G protein-coupled receptor 17 (GPR17), a membrane receptor, negatively regulates oligodendrocyte precursor cell (...
