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Article
Open AccessKAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m6A reader YTHDC1 protein degradation
Neuroblastoma (NB) patients with amplified MYCN often face a grim prognosis and are resistant to existing therapies, yet MYCN protein is considered undruggable. KAP1 (also named TRIM28) plays a crucial role in...
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Article
Open AccessLINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
Cancer stem-like cell is a key barrier for therapeutic resistance and metastasis in various cancers, including breast cancer, yet the underlying mechanisms are still elusive. Through a genome-wide lncRNA expre...
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Chapter and Conference Paper
Structure Optimization for Wide-Channel Plate Heat Exchanger Based on Interval Constraints
Wide-channel plate heat exchanger is a widely-used high performance heat exchanger, and its structure has a significant effect on heat exchange effect. However, the density and flow rate of the heat transfer m...
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Article
USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer
Cancer stem cells (CSCs) encompass a subset of highly aggressive tumor cells that are involved in tumor initiation and progression. This study investigates the function of regulator of calcineurin 2 (RCAN2) in...
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Article
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
High-risk neuroblastoma (NB) still has an unfavorable prognosis and inducing NB differentiation is a potential strategy in clinical treatment, yet underlying mechanisms are still elusive. Here we identify TRIM...
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Article
Open AccessDevelopmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats
ZF2001, a protein subunit vaccine against coronavirus disease 2019 (COVID-19), contains recombinant tandem repeat of dimeric receptor-binding domain (RBD) protein of the SARS-CoV-2 spike protein with an alumin...
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Article
An underwater attenuation image enhancement method with adaptive color compensation and detail optimization
Aiming at the problems of color compensation bias and loss of detail information in local areas of current underwater image enhancement methods, this paper proposes an underwater attenuation image enhancement ...
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Chapter and Conference Paper
A LSTM Assisted Prediction Strategy for Evolutionary Dynamic Multiobjective Optimization
Dynamic multiobjective optimization problems (DMOPs) are widely spread in real-world applications. Once the environment changes, the time-varying Pareto-optimal solutions (PS) are required to be timely tracked...
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Article
Open AccessMechanisms of linezolid resistance in Staphylococcus capitis with the novel mutation C2128T in the 23S rRNA gene in China
The objective of this study was to investigate the molecular characteristics and potential resistance mechanisms of linezolid-resistant (LZR) Staphylococcus capitis isolates from a tertiary hospital in China.
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Article
Research on the Measurement of Ship’s Tank Capacity Based on the Monte Carlo Method
Focusing on the problems of large workload, long time consumption, and high manual involvement on the current methods of the ship’s tank capacity measurement, in this study, a Monte Carlo method is applied to ...
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Article
Research on Capacity Measurement Method of Horizontal Cylindrical Tank Based on Monte Carlo Method
A horizontal cylindrical tank is a common storage device for petroleum products, and its capacity table is an important basis for calculating the volume of liquid poured into and out of the tank. In this study...
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Article
Influence of Measurement Parameters on the Accuracy of Determining the Capacity of a Vertical Tank
Vertical tanks are commonly used for oil storage. The accuracy of measurement of the tank’s capacity depends directly on the method used for processing the experimental data. When the Monte Carlo method is app...
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Article
Influence of Bubbles in Diesel Volume Measurement
Accurate measurement of diesel volume is important in both industrial and domestic applications. The accuracy of volume evaluation of diesel fuel is affected by the formation of bubbles in diesel. In this pape...
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Chapter
Head and Neck
Clinical and radiological signs are named after natural signs. This chapter summarizes the imaging features and theories regarding the pathophysiology of various relatively common head-and-neck abnormalities. ...
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Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16
Aging is characterized by the loss of homeostasis and the general decline of physiological functions, accompanied by various degenerative diseases and increased rates of mortality. Aging targeting small molecu...
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Article
Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle
Not all individuals age at the same rate. Methods such as the ‘methylation clock’ are invasive, rely on expensive assays of tissue samples and infer the ageing rate by training on chronological age, which is u...
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Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Molecular architecture of lineage allocation and tissue organization in early mouse embryo
During post-implantation development of the mouse embryo, descendants of the inner cell mass in the early epiblast transit from the naive to primed pluripotent state1. Concurrently, germ layers are formed and cel...
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Article
Author Correction: H3K14me3 genomic distributions and its regulation by KDM4 family demethylases
We apologize for an error introduced during format conversion in the paper published online on 18 October 2018. The resolution of the MALDI-TOF result in Fig. 1e underwent an unexpected reduction when transfor...
