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Article
A new approach to modeling the cure rate in the presence of interval censored data
We consider interval censored data with a cured subgroup that arises from longitudinal followup studies with a heterogeneous population where a certain proportion of subjects is not susceptible to the event of...
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Article
Improving marginal hazard ratio estimation using quadratic inference functions
Clustered and multivariate failure time data are commonly encountered in biomedical studies and a marginal regression approach is often employed to identify the potential risk factors of a failure. We consider...
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Article
Rejoinder on: Nonparametric estimation in mixture cure models with covariates
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Article
Nonparametric estimation in mixture cure models with covariates
Nonparametric estimation methods for the cure rate and the distribution of the failure time of uncured subjects with covariates for censored survival data have attracted much attention in the last few years. T...
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Chapter
A Selective Overview of Statistical Methods for Identification of the Treatment-Sensitive Subsets of Patients
Identification of a subset of patients who may benefit from or be sensitive to a specific type of treatment has become a very important research topic in clinical trials and other types of clinical research. S...
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Article
An additive hazards frailty model with semi-varying coefficients
Proportional hazards frailty models have been extensively investigated and used to analyze clustered and recurrent failure times data. However, the proportional hazards assumption in the models may not always ...
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Article
Maximum likelihood estimation for length-biased and interval-censored data with a nonsusceptible fraction
Left-truncated data are often encountered in epidemiological cohort studies, where individuals are recruited according to a certain cross-sectional sampling criterion. Length-biased data, a special case of lef...
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Article
A support vector machine based semiparametric mixture cure model
The mixture cure model is an extension of standard survival models to analyze survival data with a cured fraction. Many developments in recent years focus on the latency part of the model to allow more flexibl...
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Article
Open AccessRegion-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancer
The glucocorticoid receptor (NR3C1, GR) is frequently downregulated in breast tumors, and evidence suggests it acts as a tumor suppressor in estrogen receptor-positive (ER+) breast cancer. We previously found tha...
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Article
Open AccessImaging use for low back pain by Ontario primary care clinicians: protocol for a mixed methods study – the Back ON study
At any one time, one in every five Canadians has low back pain (LBP), and LBP is one of the most common health problems in primary care. Guidelines recommend that imaging not be routinely performed in patients...
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Article
Jointly modeling longitudinal proportional data and survival times with an application to the quality of life data in a breast cancer trial
Motivated by the joint analysis of longitudinal quality of life data and recurrence free survival times from a cancer clinical trial, we present in this paper two approaches to jointly model the longitudinal p...
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Article
Joint modeling of longitudinal proportional measurements and survival time with a cure fraction
In cancer clinical trials and other medical studies, both longitudinal measurements and data on a time to an event (survival time) are often collected from the same patients. Joint analyses of these data would...
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Chapter
Recent Development in the Joint Modeling of Longitudinal Quality of Life Measurements and Survival Data from Cancer Clinical Trials
In cancer clinical trials, longitudinal Quality of Life (QoL) measurements and survival time on a patient may be analyzed by joint models, which provide more efficient estimation than modeling QoL data and sur...
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Article
Integrating health-related quality of life findings from randomized clinical trials into practice: an international study of oncologists’ perspectives
Although health-related quality of life (HRQL) is increasingly assessed in randomized controlled trials (RCTs), HRQL findings are not always incorporated into clinical decision making. We examined the current ...
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Article
Semiparametric estimation methods for the accelerated failure time mixture cure model
This paper provides an overview of two semiparametric estimation methods recently proposed in the literature for the accelerated failure time mixture cure model. We prove that the two estimation methods are as...
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Article
An extended cure model and model selection
We propose a novel interpretation for a recently proposed Box–Cox transformation cure model, which leads to a natural extension of the cure model. Based on the extended model, we consider an important issue of...
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Article
Accelerated hazards mixture cure model
We propose a new cure model for survival data with a surviving or cure fraction. The new model is a mixture cure model where the covariate effects on the proportion of cure and the distribution of the failure ...
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Article
A marginal regression model for multivariate failure time data with a surviving fraction
A marginal regression approach for correlated censored survival data has become a widely used statistical method. Examples of this approach in survival analysis include from the early work by Wei et al. (J Am ...
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Article
Open AccessLinkage analysis of systolic blood pressure: a score statistic and computer implementation
A genome-wide linkage analysis was conducted on systolic blood pressure using a score statistic. The randomly selected Replicate 34 of the simulated data was used. The score statistic was applied to the sibshi...