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Article
Research on the thermal forming limit diagram (TFLD) with the M-K model for Ti-6Al-4V alloy
The formability of Ti-6Al-4V titanium alloy at high temperatures is critical in assisting the manufacture of aircraft components. The predicted forming limit curves (FLCs) of Ti-6Al-4V under elevated temperatu...
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Article
Open AccessDeep learning parametric response map** from inspiratory chest CT scans: a new approach for small airway disease screening
Parametric response map** (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT scans. We hypothesize that deep learning PRM fro...
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Article
Open AccessEpigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy
Checkpoint blockade immunotherapy, represented by PD-1 or PD-L1 antibody treatment, has been of tremendous success in clinical practice. However, the low clinical response rate and lack of biomarkers for predi...
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Article
Advancements in accuracy decline mechanisms and accuracy retention approaches of CNC machine tools: a review
Computer numerical control (CNC) machine tools, as advanced manufacturing equipment, have been widely used in modern manufacturing. The machining accuracy acting as a main index of performance has long been mo...
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Article
A phase I pharmacokinetic study of copanlisib in Chinese patients with relapsed indolent non-Hodgkin lymphoma
Copanlisib, a pan-PI3K inhibitor, has previously shown clinical efficacy and a tolerable safety profile in patients with indolent non-Hodgkin lymphoma. However, the pharmacokinetics, safety, tolerability, and ...
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Article
Multi-points 3D Stretch-Press-Bending Process for Forming of W-Shaped Mirror-Symmetrical Structural Parts
To improve the aerodynamic performance of high-end equipment, the mirror-symmetrically 3D curved aluminum structural parts are increasingly assembled in the manufacturing industry. A new type of multi-points 3...
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Article
Anisotropic behavior and mechanical properties of Ti-6Al-4V alloy in high temperature deformation
Uniaxial hot tensile tests were carried out in the RD, 45°, and TD directions of cold-rolled Ti-6Al-4V alloy sheets. At 973 K-0.1 s−1, it shows apparent mechanical and fracture anisotropy. Increasing temperature ...
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Article
Open AccessAuthor Correction: METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding
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Article
Open AccessMETTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding
The adenomatous polyposis coli (APC) is a frequently mutated tumour suppressor gene in cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive. In this study, we analysed TCGA da...
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Article
Open AccessMulti-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes
Primary small cell carcinoma of the esophagus (PSCCE) is a lethal neuroendocrine carcinoma. Previous studies proposed a genetic similarity between PSCCE and esophageal squamous cell carcinoma (ESCC) but provid...
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Article
Open AccessContrast medium administration with a body surface area protocol in step-and-shoot coronary computed tomography angiography with dual-source scanners
We evaluated the feasibility and image quality of prospective electrocardiography (ECG)-triggered coronary computed tomography angiography (CCTA) using a body surface area (BSA) protocol for contrast-medium (C...
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Article
Open AccessRadiomics for lung adenocarcinoma manifesting as pure ground-glass nodules: invasive prediction
To investigate the value of radiomics based on CT imaging in predicting invasive adenocarcinoma manifesting as pure ground-glass nodules (pGGNs).
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Article
Characteristics of Speciated Mercury Emissions from Coal Combustion in Air and Oxygen-Enriched Environment
Coal combustion is a dominant source of Hg in atmosphere and is believed to be responsible for increases of atmospheric Hg since industrial revolution. In this study, we compared characteristics of different H...
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Article
Open AccessLower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining
Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) share many common features, including similar morphology, gene expression and in vitro differentiation profiles. However, genomic stabilit...
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Article
Application of liquid biopsy in precision medicine: opportunities and challenges
Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosis and treatment of individuals. Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) i...
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Article
DNA methylation signatures in circulating cell-free DNA as biomarkers for the early detection of cancer
Detecting cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) in plasma or serum could serve as a “liquid biopsy”, which would be useful for numerous diagnostic applications. cfDNA methylation detection is ...
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Protocol
Functional Characterization of ATM Kinase Using Acetylation-Specific Antibodies
The activation of ATM is critical in the DNA double strand breaks repair pathway. Acetylation of ATM by Tip60 histone acetyltransferase (HAT) plays a key role in the activation of ATM kinase activity in respon...
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Article
Open AccessThe estrogenicity of methylparaben and ethylparaben at doses close to the acceptable daily intake in immature Sprague-Dawley rats
The estrogenicity of parabens at human exposure levels has become a focus of concern due to the debate over whether the estrogenicity of parabens is strong enough to play a role in the increased incidence of b...
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Article
GATA family members as inducers for cellular reprogramming to pluripotency
Members of the GATA protein family play important roles in lineage specification and transdifferentiation. Previous reports show that some members of the GATA protein family can also induce pluripotency in som...
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Article
Open AccessRole of Tip60 tumor suppressor in DNA repair pathway
To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms. The ubiquitously expressed acetyltransferase, Tip60, plays a central role in...
