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Article
Open AccessBeta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory fac...
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Article
Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk
Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type–specific mechanisms of complex diseases. Since pancreatic islets are centr...
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Article
Ore fluid of the Tielu** silver deposit of Henan Province and its illustration of the tectonic model for collisional petrogenesis, metallogenesis and fluidization
The Tielu** silver deposit, located in the NE-trending faults within the metamorphic basement of the **ong'er Mountain, is a typical altered fracture type deposit. Its ore-forming process includes three stag...
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Article
Progress and records in the study of endogenetic mineralization during collisional orogenesis
To develop and perfect the theory of plate tectonics and regional metallogeny, metallogenesis during collisional orogenesis should be thoroughly studied and will attract increasing attention of more and more s...
