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Article
A Phase I, Open-Label, Mass Balance Study of [14C]-Iberdomide in Healthy Subjects
Iberdomide is a novel potent cereblon modulator (CELMoD®) agent, which is currently under clinical development for hematological malignancies. A human mass balance study was conducted to characterize the biotrans...
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Article
The value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation for detecting papillary thyroid carcinoma in cytologically indeterminate thyroid nodules
To investigate the value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation in the detection of papillary thyroid carcinoma (PTC)within cytologically ind...
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Article
A Bionic Stick–Slip Piezo-Driven Positioning Platform Designed by Imitating the Structure and Movement of the Crab
By imitating the body structure and movement mode of the crab in nature, a novel stick–slip piezo-driven positioning platform was proposed by employing the bionic flexible hinge mechanism with a symmetrical st...
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Article
Open AccessBlood transcriptomics mirror regulatory mechanisms during hibernation—a comparative analysis of the Djungarian hamster with other mammalian species
Hibernation enables many species of the mammalian kingdom to overcome periods of harsh environmental conditions. During this physically inactive state metabolic rate and body temperature are drastically downre...
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Chapter and Conference Paper
Design of Small Satellite Power Supply Interface Test System Based on PXI Bus
This paper investigates the design scheme of intelligent power supply interface test system for small satellites in order to satisfy the requirements of mass production of small satellites and achieve the goal...
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Article
Risk management in sustainable supply chain: a knowledge map towards intellectual structure, logic diagram, and conceptual model
The global spread of COVID-19, international trade protectionism, geopolitical conflicts, and climate change presents challenges and risks to sustainable supply chains (SSCs). In recent years, scholarly intere...
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Article
An Open Label, Phase 1, Randomized, Seven-treatment, Seven-period, Crossover Study to Assess the Relative Bioavailability, pH Effect, Food Effect, and Dose Proportionality of CC-292, a Potent and Orally Available Bruton’s Tyrosine Kinase Inhibitor
CC-292 is a potent, selective, orally administered small molecule inhibitor of Bruton’s tyrosine kinase (BTK). To support the clinical investigation of CC-292, a randomized, seven-treatment, seven-period, cros...
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Article
Biphasic Effects of Ethanol Exposure on Waste Metabolites Clearance in the CNS
We have shown that the effects of low-dose ethanol promote the clearance of waste metabolites, such as amyloid-beta (Aβ) proteins, from the brain through the perivascular space (PVS). We demonstrated that dila...
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Article
Hemorrhage Associated Mechanisms of Neuroinflammation in Experimental Traumatic Brain Injury
Traumatic brain injury (TBI) is a major health problem for over 3.17 million people in the US, attracting increasing public attentions. Understanding the underlying mechanism of TBI is urgent for better diagno...
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Article
Open AccessJMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity
The initiation and transduction of DNA damage response (DDR) occur in the context of chromatin, and modifications as well as the structure of chromatin are crucial for DDR signaling. How the profound chromatin...
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Chapter and Conference Paper
ConvCaps: Multi-input Capsule Network for Brain Tumor Classification
Brain tumor is considered one of the most deadly cancer. Determining the type of brain tumor has a significant effect on the choice of treatment and improves the survival rate of the patients. In general, man...
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Protocol
Prediction of Mitochondrial Protein Function by Comparative Physiology and Phylogenetic Profiling
According to the endosymbiotic theory, mitochondria originate from a free-living alpha-proteobacteria that established an intracellular symbiosis with the ancestor of present-day eukaryotic cells. During the b...
