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Article
Open AccessIntegrated PBPK-EO modeling of osimertinib to predict plasma concentrations and intracranial EGFR engagement in patients with brain metastases
The purpose of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model combined with an EGFR occupancy (EO) model for osimertinib (OSI) to predict plasma trough concentratio...
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Article
In situ reconstruction induced oxygen-deficient multiphase Cu based species hybridized with Ni single atoms as tandem platform for CO2 electroreduction
Tandem catalysis, capable of decoupling individual steps, provides a feasible way to build a high-efficiency CO2 electroconversion system for multicarbons (C2+). The construction of electrocatalytic materials is ...
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Article
Open AccessA qualitative study on patients’ and health care professionals’ perspectives regarding care delivered during CIED operation
Cardiac implantable electronic devices (CIEDs) has proven to be an invaluable tool in the practice of cardiology. Patients who have undergone CIED surgery with local anesthesia may result in fear, insecurity a...
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Article
An Ultra-low Detection Limit Fe3+ Optical Fiber Fluorescent Sensor Based on a Anti-B18H22 Derivative with Aggregation-induced Emission Enhancement
A fluorescent Fe3+ probe ((C10H7NO2)2B18H20, M1) by introducing two isoquinoline-1-carboxylic acid group into the 6,9-position of anti-B18H22 was designed and synthesized. The structure of M1 was investigated by
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Article
Online machine learning for stream wastewater influent flow rate prediction under unprecedented emergencies
Accurate influent flow rate prediction is important for operators and managers at wastewater treatment plants (WWTPs), as it is closely related to wastewater characteristics such as biochemical oxygen demand (...
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Article
Preparation of novel HKUST-1-glucose oxidase composites and their application in biosensing
Copper-based metal–organic frameworks (MOF) and multi-walled carbon nanotubes (HKUST-1-MWCNTs) composite were synthesized by one-step hydrothermal method, and PDA-enzyme-HKUST-1-MWCNTs composite was prepared b...
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Article
Implementation of an integrated health risk assessment coupled with spatial interpolation and source contribution: a case study of soil heavy metals from an abandoned industrial area in Suzhou, China
Soil heavy metal contaminated sites with multiple sources of pollution have caused worldwide public concern. However, the lack of correlation of risk assessment between source identification of heavy metal lea...
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Article
Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis
Cell-free based therapy is an effective strategy in regenerative medicine as it avoids controversial issues, such as immunomodulation and stability. Recently, exosomes have been explored as a favorable substit...
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Article
The SR-protein FgSrp2 regulates vegetative growth, sexual reproduction and pre-mRNA processing by interacting with FgSrp1 in Fusarium graminearum
Serine/arginine (SR) proteins play significant roles in pre-mRNA splicing in eukaryotes. To investigate how gene expression influences fungal development and pathogenicity in Fusarium graminearum, a causal agent ...
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Article
Open AccessTranscriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response
The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression, growth and differentiation, has been extensively investigated. However, metabolic r...
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Article
Covalent immobilization of lipases on monodisperse magnetic microspheres modified with PAMAM-dendrimer
This paper reported an immobilization of Candida rugosa lipase (CRL) onto PAMAM-dendrimer-grafted magnetic nanoparticles synthesized by a modified solvothermal reduction method. The dendritic magnetic nanopartic...
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Article
Filamin A expression correlates with proliferation and invasive properties of human metastatic melanoma tumors: implications for survival in patients
Filamin A (FLNa) cross-links actin filaments into dynamic orthogonal networks and interacts with binding proteins of diverse cellular functions that are implicated in cell growth and motility regulation. Here...
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Article
A semiparametric statistical approach for forecasting SO2 and NO x concentrations
This study develops a new semiparametric statistical approach for urban air quality forecasting. Compared to conventional approaches, the semiparametric approach allows the model users to benefit from the posi...
