7 Result(s)
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Article
Open AccessTannic acid modified keratin/sodium alginate/carboxymethyl chitosan biocomposite hydrogels with good mechanical properties and swelling behavior
Natural polymer-based hydrogels have demonstrated great potential as wound-healing dressings. They help to maintain a moist wound environment as well as promote faster healing. In this work, a multifunctional ...
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Open AccessIntegrated PBPK-EO modeling of osimertinib to predict plasma concentrations and intracranial EGFR engagement in patients with brain metastases
The purpose of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model combined with an EGFR occupancy (EO) model for osimertinib (OSI) to predict plasma trough concentratio...
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Article
Open AccessUnderstanding the physical mechanism of intrinsic noise inside viscous isotropic solids
We report acoustic impulse-response and system function of particle vibration inside viscous, dense solids and explain the physical mechanism of intrinsic-noise generation. With an external disturbance of a ha...
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Open AccessGraphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy
In the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier to improve the process of tumor-targeted drug releases, promote cellular uptake and accumulation of chemotherapy drugs i...
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Article
Open AccessGastrin releasing peptide receptor targeted nano-graphene oxide for near-infrared fluorescence imaging of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor that occurs in the oral mucosa. Pathological biopsy is still the current gold standard for OSCC diagnosis; however, some drawbacks need to...
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Article
Open AccessOptimization of Treatment Geometry to Reduce Normal Brain Dose in Radiosurgery of Multiple Brain Metastases with Single–Isocenter Volumetric Modulated Arc Therapy
Treatment of patients with multiple brain metastases using a single-isocenter volumetric modulated arc therapy (VMAT) has been shown to decrease treatment time with the tradeoff of larger low dose to the norma...
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Article
Open AccessQuantum Spin Hall States in Stanene/Ge(111)
For topological insulators to be implemented in practical applications, it is a prerequisite to select suitable substrates that are required to leave insulators’ nontrivial properties and sizable opened band g...
