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Article
Activating MC4R Promotes Functional Recovery by Repressing Oxidative Stress-Mediated AIM2 Activation Post-spinal Cord Injury
Spinal cord injury (SCI) is a destructive neurological trauma that induces permanent sensory and motor impairment as well as a deficit in autonomic physiological function. Melanocortin receptor 4 (MC4R) is a G...
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Article
Failure mechanism and combined bearing capacity of monopile–friction wheel hybrid foundation in sand-over-clay deposit
Monopile–friction wheel hybrid foundations have gradually become a promising foundation type for the high-capacity offshore wind turbines. Compared with traditional offshore foundations, monopile–friction whee...
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Article
Open AccessUnderstanding internal migration in the UK before and during the COVID-19 pandemic using twitter data
The COVID-19 pandemic has greatly affected internal migration patterns and may last beyond the pandemic. It raises the need to monitor the migration in an economical, effective and timely way. Benefitting from...
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Article
Identifying the predictive effectiveness of a genetic risk score for incident hypertension using machine learning methods among populations in rural China
Current studies have shown the controversial effect of genetic risk scores (GRSs) in hypertension prediction. Machine learning methods are used extensively in the medical field but rarely in the mining of gene...
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Article
Open AccessGenetic factors increase the identification efficiency of predictive models for dyslipidaemia: a prospective cohort study
Few studies have developed risk models for dyslipidaemia, especially for rural populations. Furthermore, the performance of genetic factors in predicting dyslipidaemia has not been explored. The purpose of thi...
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Article
Open AccessIndependent and interactive effect of sitting time and physical activity on prevalence of hyperuricemia: the Henan Rural Cohort Study
There are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) and also hardly regarding sitting time (ST). The purpose of this study was to examine the independent ...
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Article
Open AccessDose-response association of sleep quality with anxiety symptoms in Chinese rural population: the Henan rural cohort
The epidemiological evidence on the association of sleep quality on anxiety symptoms has been inconclusive. This study aimed to explore the association between sleep quality and anxiety symptoms in rural Chine...
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Article
Open AccessMachine learning for characterizing risk of type 2 diabetes mellitus in a rural Chinese population: the Henan Rural Cohort Study
With the development of data mining, machine learning offers opportunities to improve discrimination by analyzing complex interactions among massive variables. To test the ability of machine learning algorithm...
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Article
Open AccessAdiposity reduces the risk of osteoporosis in Chinese rural population: the Henan rural cohort study
Adiposity plays a crucial role in the risk of osteoporosis. However, the impact of body fat distribution on the skeleton is contentious. The study was designed to explore the association of various adiposity i...
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Article
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
The anti-apoptotic function of the 70 kDa family of heat shock proteins and their role in cancer is well documented. Dual targeting of Hsc70 and Hsp70 with siRNA induces proteasome-dependent degradation of Hsp...
