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  1. Article

    Open Access

    Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

    DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase...

    Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin… in Molecular Neurodegeneration (2023)

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  2. Article

    Open Access

    Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

    Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP–AM...

    Joe C. Udeochu, Sadaf Amin, Yige Huang, Li Fan… in Nature Neuroscience (2023)

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  3. No Access

    Article

    A legume kinesin controls vacuole morphogenesis for rhizobia endosymbiosis

    Symbioses between legumes and rhizobia require establishment of the plant-derived symbiosome membrane, which surrounds the rhizobia and accommodates the symbionts by providing an interface for nutrient and sig...

    **axia Zhang, Qi Wang, **gxia Wu, Meifang Qi, Chen Zhang, Yige Huang… in Nature Plants (2022)

  4. No Access

    Article

    The expression of diacylglycerol kinase isoforms α and ζ correlates with the progression of experimental autoimmune encephalomyelitis in rats

    Multiple sclerosis (MS) is characterized by neuroinflammation and neurodegeneration, whose precise processes are not fully understood. Diacylglycerol kinase (DGK) isozymes of α, β, γ and ζ expressed abundantly...

    Huilin Cui, Yige Huang, Ying Wu, **feng Ma, **mei Cao… in Histochemistry and Cell Biology (2021)

  5. No Access

    Article

    Transfer cells mediate nitrate uptake to control root nodule symbiosis

    Root nodule symbiosis enables nitrogen fixation in legumes and, therefore, improves crop production for sustainable agriculture1,2. Environmental nitrate levels affect nodulation and nitrogen fixation, but the me...

    Qi Wang, Yige Huang, Zhijie Ren, **axia Zhang, **g Ren, Jiaqi Su… in Nature Plants (2020)