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Article
Open AccessCRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-...
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Article
Open AccessNovel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations
Despite the efficacy of absolute ethanol (EtOH), its radiolucency introduces several risks in interventional therapy for treating vascular malformations. This study aims to develop a novel radiopaque ethanol i...
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Article
Open AccessY4 RNA fragments from cardiosphere-derived cells ameliorate diabetic myocardial ischemia‒reperfusion injury by inhibiting protein kinase C β-mediated macrophage polarization
The specific pathophysiological pathways through which diabetes exacerbates myocardial ischemia/reperfusion (I/R) injury remain unclear; however, dysregulation of immune and inflammatory cells, potentially dri...
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Article
Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles
Conventional antibiotics used for treating tuberculosis (TB) suffer from drug resistance and multiple complications. Here we propose a lesion–pathogen dual-targeting strategy for the management of TB by coating M...
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Article
Open AccessIdentification of a pathogenic SMCHD1 variant in a Chinese patient with bosma arhinia microphthalmia syndrome: a case report
Bosma arhinia microphthalmia syndrome (BAMS; MIM603457) is a rare genetic disorder, predominantly autosomal dominant. It is a multi-system developmental disorder characterized by severe hypoplasia of the nose ...
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Article
The Influence of Rock Morphology and Distribution on the Bearing Capacity and the Sliding Surface of Soil–Rock Embankment
Soil–rock mixture, a non-homogeneous medium with discrete characteristics, is commonly used in high-fill projects. This study analyzes the impact of rock morphology and distribution on the ultimate bearing cap...
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Article
Open AccessThe impact of PET/CT and brain MRI for metastasis detection among patients with clinical T1-category lung cancer: Findings from a large-scale cohort study
[18F]-FDG PET/CT and brain MRI are common approaches to detect metastasis in patients of lung cancer. Current guidelines for the use of PET/CT and MRI in clinical T1-category lung cancer lack risk-based stratific...
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Article
Corporate greenhushing and stock price crash risk: evidence from China
As sustainability gains momentum, there is a growing expectation for companies to enhance their environmental disclosures. However, a contrasting trend has emerged: corporate greenhushing. This phenomenon enta...
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Article
Development of Kinetic Inductance Bolometers for the Space High-Cadence Observing Telescope
The Space High-Cadence Observing Telescope (SHOT) is proposed as a spaceborne 0.8-meter terahertz camera with remarkable imaging speed, aimed at conducting the inaugural large-sky terahertz survey and unlockin...
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Article
Efficacy of transauricular vagus nerve stimulation for the treatment of chemotherapy-induced painful peripheral neuropathy: a randomized controlled exploratory study
Chemotherapy-induced painful peripheral neuropathy (CIPN) is a common adverse event in cancer patients, and there is still a lack of effective treatment. Transauricular vagal nerve stimulation (taVNS) is a min...
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Article
Open-air plasma-assisted deposition of organosilicon coating for corrosion protection of AZ91D Mg alloy
As a corrosion barrier layer, open-air plasma-assisted organosilicon coating was applied on AZ91D Mg alloy. Organosilicon-coated AZ91D samples, prepared from two different plasma coating processes, were used f...
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Article
Develo** Assistive Technology Products Based on Experiential Learning for Elderly Care
This study aimed to understand the challenges faced by assistive technology developers when designing products for elderly care and to explore how experiential learning shapes their design experiences. This qu...
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Article
Open AccessMiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway
Micro RNAs (miRs) have been implicated in various tumorigenic processes. Osteosarcoma (OS) is a primary bone malignancy seen in adolescents. However, the mechanism of miRs in OS has not been fully demonstrated...
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Article
Open AccessThe activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial
Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage grou...
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Article
A discovery of two slow pulsars with FAST: “Ronin” from the globular cluster M15
Globular clusters harbor numerous millisecond pulsars, but long-period pulsars (P ≳ 100 ms) are rarely found. In this study, we employed a fast folding algorithm to analyze observational data from multiple globul...
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Article
Open AccessCold EMR vs. Hot EMR for the removal of sessile serrated polyps larger than 10 mm: a systematic review and meta-analysis
Endoscopic mucosal resection (EMR) appears to be a promising technique for the removal of sessile serrated polyps (SSPs) ≥ 10 mm. To assess the effectiveness and safety of EMR for removing SSPs ≥ 10 mm, we con...
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Article
L-Type Calcium Channel Modulates Low-Intensity Pulsed Ultrasound-Induced Excitation in Cultured Hippocampal Neurons
As a noninvasive technique, ultrasound stimulation is known to modulate neuronal activity both in vitro and in vivo. The latest explanation of this phenomenon is that the acoustic wave can activate the ion channe...
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Article
Open AccessRNA-seq analysis of chlorogenic acid intervention in duck embryo fibroblasts infected with duck plague virus
Chlorogenic acid, the primary active component in Chinese medicines like honeysuckle, exhibits anti-inflammatory and antiviral effects. It has been demonstrated that chlorogenic acid effectively prevents and t...
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Article
Open AccessTraditional knowledge of animal-derived medicines used by Gelao community in Northern Guizhou, China
This study aims to document and preserve the traditional medicinal knowledge of the Gelao community in Northern Guizhou, China, providing valuable insights for modern pharmacological research and the developme...
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Article
Open AccessPsychometric properties of the Chinese version of the Gudjonsson compliance scale: scale validation and associations with mental health
Trait compliance involves people reacting favorably to demands made by others across different situations. This may lead to susceptibility to external pressures, exploitation, and manipulation. Moreover, trait...
