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Article
Open AccessOrganophotocatalysed synthesis of 2-piperidinones in one step via [1 + 2 + 3] strategy
Six-membered N-containing heterocycles, such as 2-piperidinone derivatives, with diverse substitution patterns are widespread in natural products, drug molecules and serve as key precursors for piperidines. Thus,...
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Article
Open AccessMicrobiome diversity of cotton aphids (Aphis gossypii) is associated with host alternation
Aphids are infected by a series of bacteria that can help them survive on specific host plants. However, the associations between aphids and these bacteria are not clear, and the bacterial communities in many ...
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Article
Open AccessCognitive impairment and associated risk factors in older adult hemodialysis patients: a cross-sectional survey
The clinical epidemiological features of cognitive impairment in Chinese older adult patients undergoing hemodialysis are not clear, we aimed to identify the extent and patterns of cognitive impairment among t...
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Article
Open AccessMRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-lo...
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Article
Open AccessImmunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract
Fusobacterium nucleatum (Fn) is an important tumour-associated bacterium in colorectal cancer (CRC). The antioxidant protein alkyl hydroperoxide reductase subunit C (AhpC) can induce stro...
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Article
Open AccessCharacterization of transcriptional modules related to fibrosing-NAFLD progression
Based on the severity of liver fibrosis, low or high-risk profile of develo** end-stage liver disease was present in nonalcoholic fatty liver disease (NAFLD). However, the mechanisms inducing transition from...
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Article
Open AccessLichen elemental composition distinguishes anthropogenic emissions from dust storm inputs and differs among species: Evidence from **linhot, Inner Mongolia, China
To test the applicability of lichens in the biomonitoring of atmospheric elemental deposition in a typical steppe zone of Inner Mongolia, China, six foliose lichens (Physcia aipolia, PA; P. tribacia, PT; Xanthori...
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Article
Open AccessActivation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes
Infection by the dengue virus (DENV) threatens global public health due to its high prevalence and the lack of effective treatments. Host factors may contribute to the pathogenesis of DENV; herein, we investig...