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Article
Open AccessThe impact of incident stroke on cognitive trajectories in later life
Cognitive impairment is common after stroke, and a large proportion of stroke patients will develop dementia. However, there have been few large prospective studies which have assessed cognition both prior to ...
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Article
Open AccessPrediction of disability-free survival in healthy older people
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-n...
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Article
Trajectories of depressive symptoms in older adults and associated health outcomes
With the progressive aging of the world’s population, prolongation of a healthy lifespan in old age has become a medical research priority. The presence of depressive symptoms in later life is associated with ...
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Article
Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults
Recent epidemiological evidence has suggested that use of lipid-lowering medications, particularly statins, was associated with reduced cardiovascular disease (CVD) events and persistent physical disability in...
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Article
Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial
Late-life depression is common and often inadequately managed using existing therapies. Depression is also associated with increased markers of inflammation, suggesting a potential role for anti-inflammatory a...
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Article
Health-related quality of life and all-cause mortality among older healthy individuals in Australia and the United States: a prospective cohort study
Previous research has demonstrated that lower health-related quality of life (HRQoL) is associated with higher morbidity and mortality, especially in-patient groups. The association of HRQoL with all-cause mor...
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Article
The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study
Cardiovascular drugs impact many pathways involved in depression pathophysiology and treatment. However, their distinct impact on mood is underrecognized and the literature is conflicting. Therefore, using a v...
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Article
Open AccessCognitive impairment and associated risk factors in older adult hemodialysis patients: a cross-sectional survey
The clinical epidemiological features of cognitive impairment in Chinese older adult patients undergoing hemodialysis are not clear, we aimed to identify the extent and patterns of cognitive impairment among t...
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Article
Open AccessThe Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
Population health research is increasingly focused on the genetic determinants of healthy ageing, but there is no public resource of whole genome sequences and phenotype data from healthy elderly individuals. ...
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Article
Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study
Statin use has been frequently associated with depressive symptoms in an older population. However, the nature of this association is uncertain in the literature. In this study, we aimed to investigate the ass...
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Article
Quality of Life for 19,114 participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study and their association with sociodemographic and modifiable lifestyle risk factors
To explore the relationship between sociodemographic and lifestyle variables with health-related quality of life (HRQoL) of a large cohort of ‘healthy’ older individuals.
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Article
ACCORDION MIND: results of the observational extension of the ACCORD MIND randomised trial
The Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, a double 2x2 factorial parallel-group randomised clinical trial, tested whether intensive compare...
