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Article
mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning
Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated with schizophrenia. mGluR...
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Article
Optimal design approach for eco-efficient machine tool bed
An optimal design approach of machine tool bed with the aim of obtaining an eco-efficient machine structure is studied. The suggested method includes three phases. The first is the layout design optimization o...
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Chapter and Conference Paper
Cross-Category Cross-Semantic Regularization for Fine-Grained Image Recognition
Fine-grained image recognition (FGIR) is challenging due to the local and subtle differences between subordinate categories. Existing methods adopt a two-step strategy by first detecting local parts from image...
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Article
Open AccessUbiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived protein...
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Article
Open AccessGluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats
Anesthetics are used to produce hypnosis and analgesic effects during surgery, but anesthesia for a long time after the operation is not conducive to the recovery of animals or patients. Therefore, finding app...
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Article
Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies
TDP-43 proteinopathy is linked to neurodegenerative diseases that feature synaptic loss in the cortex and hippocampus, although it remains unclear how TDP-43 regulates mature synapses. We report that, in adult...
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Article
GluN2A mediates ketamine-induced rapid antidepressant-like responses
Ketamine was thought to induce rapid antidepressant responses by inhibiting GluN2B-containing N-methyl-d-aspartic acid (NMDA) receptors (NMDARs), which presents a promising opportunity to develop better antidepre...
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Article
Open AccessQuantifying the effects of practicing a semantic task according to subclinical schizotypy
The learning ability of individuals within the schizophrenia spectrum is crucial for their psychosocial rehabilitation. When selecting a treatment, it is thus essential to consider the impact of medications on...
