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GluN2A mediates ketamine-induced rapid antidepressant-like responses

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  1. Article

    Open Access

    Quantifying the effects of practicing a semantic task according to subclinical schizotypy

    The learning ability of individuals within the schizophrenia spectrum is crucial for their psychosocial rehabilitation. When selecting a treatment, it is thus essential to consider the impact of medications on...

    Mingyi Diao, Ilya Demchenko, Gifty Asare, Yelin Chen… in Scientific Reports (2024)

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  2. Article

    Open Access

    GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats

    Anesthetics are used to produce hypnosis and analgesic effects during surgery, but anesthesia for a long time after the operation is not conducive to the recovery of animals or patients. Therefore, finding app...

    Chunzhu Li, Jia Yan, Dewei Tang, Jidong Zhu, Chen Huang, Yu Sun… in Scientific Reports (2020)

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  3. Article

    Open Access

    Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker

    The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived protein...

    Lu Yang, Zaijun Ma, Han Wang, Kongyan Niu, Ye Cao, Le Sun… in Nature Communications (2019)

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  4. Article

    mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

    Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat positive symptoms associated with schizophrenia. mGluR...

    Jennifer E Ayala, Yelin Chen, Jessica L Banko… in Neuropsychopharmacology (2009)

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