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  1. No Access

    Article

    Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells

    Therapeutic genome editing of haematopoietic stem cells (HSCs) would provide long-lasting treatments for multiple diseases. However, the in vivo delivery of genetic medicines to HSCs remains challenging, espec...

    **zhen Lian, Sumanta Chatterjee, Yehui Sun, Sean A. Dilliard… in Nature Nanotechnology (2024)

  2. Article

    Open Access

    Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models

    Approximately 10% of Cystic Fibrosis (CF) patients, particularly those with CF transmembrane conductance regulator (CFTR) gene nonsense mutations, lack effective treatments. The potential of gene correction thera...

    Tuo Wei, Yehui Sun, Qiang Cheng, Sumanta Chatterjee… in Nature Communications (2023)

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  3. Article

    Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery

    A new methodology termed selective organ targeting (SORT) was recently developed that enables controllable delivery of nucleic acids to target tissues. SORT lipid nanoparticles (LNPs) involve the inclusion of ...

    Xu Wang, Shuai Liu, Yehui Sun, Xueliang Yu, Sang M. Lee, Qiang Cheng… in Nature Protocols (2023)

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  4. No Access

    Chapter and Conference Paper

    Single-Binocular Vision Conversion Strategy for Obstacle Detection at Non-signalized Intersections

    Taking full account of the advantages and disadvantages of monocular vision and binocular vision in environmental perception, this paper proposes a single-binocular vision conversion strategy based on monocula...

    **aotian Ma, **aoqing Sang, Yehui Sun… in Pervasive Systems, Algorithms and Networks (2019)