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Article
Open AccessArsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma
The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy and immunotherapy. Arsenic trioxide (ATO) has emer...
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Article
Open AccessErratum: Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma
Nature Communications 7: Article number: 12992 (2016); Published: 5 October 2016; Updated: 8 November 2016 The original version of this Article contained an error in the spelling of the author Tin-Lap Lee, whi...
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Article
Open AccessGenomic and oncogenic preference of HBV integration in hepatocellular carcinoma
Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we ...
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Article
Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein
Increasing evidence suggests that TLR4 expression by tumour cells promotes tumour progression, but it is unclear whether TLR4 is involved in metastasis. Here we show that TLR4 deficiency significantly diminishes ...
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Article
CKAP4 inhibited growth and metastasis of hepatocellular carcinoma through regulating EGFR signaling
CKAP4, one kind of type II trans-membrane protein, plays an important role to maintain endoplasmic reticulum structure and inhibits the proliferation of bladder cancer cells by combining its ligand anti-prolif...
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Article
The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling
p28GANK (also known as PSMD10 or gankyrin) is a novel oncoprotein that is highly expressed in hepatocellular carcinoma (HCC). Through its interaction with various proteins, p28GANK mediates the degradation of the...
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Article
Open AccessZinc finger protein ZBTB20 expression is increased in hepatocellular carcinoma and associated with poor prognosis
Our previous studies showed that ZBTB20, a new BTB/POZ-domain gene, could negatively regulate α feto-protein and other liver-specific genes, concerning such as bio-transformation, glucose metabolism and the re...
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Protocol
Analysis of Microdissected Cells by Two-Dimensional LC-MS Approaches
Laser capture microdissection (LCM) is a powerful tool that enables the isolation of specific cell types from tissue sections, overcoming the problem of tissue heterogeneity and contamination. We combined the ...
