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Protocol
Identification of Host Factors of Paramyxoviruses by siRNA Genome-Wide Screens
Measles is a highly infectious disease that continues to spread mainly in develo** countries, often resulting in child mortality. Despite the existence of effective vaccines, no specific antivirals are avail...
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Article
An RNA-centric dissection of host complexes controlling flavivirus infection
Flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), cause severe human disease. Co-opting cellular factors for viral translation and viral genome replication at the endoplasmic reticulum is a sh...
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Article
Enterovirus pathogenesis requires the host methyltransferase SETD3
Enteroviruses (EVs) comprise a large genus of positive-sense, single-stranded RNA viruses whose members cause a number of important and widespread human diseases, including poliomyelitis, myocarditis, acute fl...
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Article
SETD3 is an actin histidine methyltransferase that prevents primary dystocia
For more than 50 years, the methylation of mammalian actin at histidine 73 has been known to occur1. Despite the pervasiveness of His73 methylation, which we find is conserved in several model animals and plants,...
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Article
Open AccessSTAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
Cohesin is a multi-subunit nuclear protein complex that coordinates sister chromatid separation during cell division. Highly frequent somatic mutations in genes encoding core cohesin subunits have been reporte...
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Article
A CRISPR toolbox to study virus–host interactions
Viruses are obligate intracellular pathogens that depend on host cellular components for replication.
Genet...
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Article
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and ot...
