7 Result(s)

Article

Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis

Conceição Bettencourt, Ignazio S. Piras… in Acta Neuropathologica Communications (2020)

Article

White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy

Multiple system atrophy (MSA) is a fatal late-onset neurodegenerative disease. Although presenting with distinct pathological hallmarks, which in MSA consist of glial cytoplasmic inclusions (GCIs) containing f...

Conceição Bettencourt, Sandrine C. Foti, Yasuo Miki, Juan Botia… in Acta Neuropathologica (2020)

Article

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studi...

Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki… in Acta Neuropathologica Communications (2019)

Article

Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy

The histological hallmark of multiple system atrophy (MSA) is the presence of filamentous aggregations of phosphorylated α-synuclein in oligodendrocytes, referred to as glial cytoplasmic inclusions (GCIs). Alt...

Keiko Nakamura, Fumiaki Mori, Tomoya Kon… in Acta Neuropathologica Communications (2015)

Article

Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain

Extensive research on p62 has established its role in oxidative stress, protein degradation and in several diseases such as Paget’s disease of the bone, frontotemporal lobar degeneration and amyotrophic latera...

Kunikazu Tanji, Yasuo Miki, Taku Ozaki… in Acta Neuropathologica Communications (2014)