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Article
Olverembatinib combined with blinatumomab in treating T315I-mutated Philadelphia chromosome–positive acute lymphoblastic leukemia: two-case report
ABL tyrosine kinase inhibitors (TKIs) act an irreplaceable role in the management of Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). The treatment of these diseases has been revoluti...
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Article
Open AccessPrevalence of suicide attempts and correlates among first-episode and untreated major depressive disorder patients with comorbid dyslipidemia of different ages of onset in a Chinese Han population: a large cross-sectional study
Patients with dyslipidemia are at increased risk for suicide, especially those with major depressive disorder (MDD). Few studies have investigated the independent effects of suicide attempts on comorbid dyslip...
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Chapter and Conference Paper
Protein-Ligand Binding Affinity Prediction Based on Deep Learning
The identification of novel drug target (DT) interactions is an important part of the drug discovery process. A large number of studies have investigated whether DT interacts through dichotomies, yet the stren...
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Chapter and Conference Paper
Drug-Target Interaction Prediction Based on Transformer
The identification of drug-target interaction (DTI) is the crucial challenge in virtual screening, which plays a key role in drug discovery. Recently, large amounts of deep learning methods have been applied t...
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Article
Open AccessCRISPR/Cas9-mediated knockout of APOC3 stabilizes plasma lipids and inhibits atherosclerosis in rabbits
High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. We aim to create APOC3-knockout (KO) rabbits and explore the effects of APOC3 dele...
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Article
Open AccessActivation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model
Brain injury has been proposed as the major cause of the poor outcomes associated with intracerebral hemorrhage (ICH). Emerging evidence indicates that the nuclear receptor, peroxisome proliferator-activated r...
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Article
Open AccessSeveral circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases
In recent years, an increasing number of studies have proved that circulating miRNAs could be used for the early diagnosis of cardiovascular diseases and even play vital roles in the evaluation of therapeutic ...
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Article
Open AccessGeneration of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system
To generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis.
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Article
Effects of indigo carmine concentration on the morphology and microwave absorbing behavior of PPy prepared by template synthesis
In the study, a series of polypyrrole (PPy) samples were prepared by a method of template synthesis at different indigo carmine (IC) concentrations while kee** the amount of pyrrole and FeCl3 as well as the rea...
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Chapter and Conference Paper
Automatic Switching System of Voltage Pulse and Current Pulse Test in Phase Change Memory Devices
Voltage pulse and current pulse test of phase change memory (PCM) device is realized by computer controlling pulse generator, digital source meter, current pulse generating circuit, switching circuit and other...
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Article
Open AccessToxoplasma gondii and Neospora caninum in farm-reared ostriches (Struthio camelus) in China
The parasites Toxoplasma gondii (T. gondii) and Neospora caninum (N. caninum) are globally distributed; they infect warm-blooded animals, including many avian species. The aim of this study was to evaluate the pr...
