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Article
Open AccessGenetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau
Domestication and introduction of dairy animals facilitated the permanent human occupation of the Tibetan Plateau. Yet the history of dairy pastoralism in the Tibetan Plateau remains poorly understood. Little ...
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Article
High Arterial Oxygen Saturation in the Acclimatized Lowlanders Living at High Altitude
Blood oxygen saturation (SpO2) is a key indicator of oxygen availability in the body. It is known that a low SpO2 at high altitude is associated with morbidity and mortality risks due to physiological hypoxemia. ...
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Article
Open AccessLarge-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans
Tibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of the adaptation remains elusive due to the poor reproducibility for detecting select...
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Article
Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations
Birth weight (BW) is a key determinant of infant mortality. Previous studies have reported seasonal fluctuation of BW. However, the responsible environmental factors remain disputable. High-altitude environmen...
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Article
Open AccessChromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting a pre...
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Article
Open AccessTrio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
CRISPR-Cas9 is a widely-used genome editing tool, but its off-target effect and on-target complex mutations remain a concern, especially in view of future clinical applications. Non-human primates (NHPs) share...
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Article
Open AccessLong-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants
We present a high-quality de novo genome assembly (rheMacS) of the Chinese rhesus macaque (Macaca mulatta) using long-read sequencing and multiplatform scaffolding approaches. Compared to the current Indian rhesu...
