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Article
Open AccessDifferential responses to immune checkpoint inhibitor dictated by pre-existing differential immune profiles in squamous cell carcinomas caused by same initial oncogenic drivers
While immune checkpoint inhibitors (ICI) were approved for head and neck squamous cell carcinomas (HNSCCs), the response rate remains relatively low. Mechanisms underlying ICI unresponsiveness versus sensitivi...
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Article
Open AccessMulti-source and multi-fault condition monitoring based on parallel factor analysis and sequential probability ratio test
The monitoring of mechanical equipment systems contains an increasing number of complex content, expanding from traditional time, and frequency information to three-dimensional data of the time, space, and fre...
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Article
Open AccessEZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation
Psoriasis is characterized by keratinocyte hyperproliferation. While significant progress has been made in understanding the molecular mechanism regulating the proliferation of keratinocytes, little is known a...
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Chapter and Conference Paper
Model-Based Intelligent Non-linear Signal Recognition for Gearbox Condition Monitoring
In this paper, a method for equipment fault diagnosis of gearbox using principal component analysis (PCA) and sequential probability ratio test (SPRT) is proposed. The method is to study and monitor the workin...
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Article
Open AccessArtery compliance in patients with rheumatoid arthritis: results from a case-control study
Atherosclerosis is one of the most common complications of rheumatoid arthritis (RA). The objective of this study is to evaluate differences in large artery compliance (C1) and small artery compliance (C2) bet...
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Article
Geomorphological site classification for the Fujian province
Geomorphological classification of the Fujian province was done based on remote-sensing imaging, digital elevation maps, and slope gradient data acquired by ArcGIS 9.2. The engineering geological units in the ...
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Article
Open AccessReport of 12 cases of ankylosing spondylitis patients treated with Tripterygium wilfordii
Description of the clinical response of 12 consecutive cases of disease-active ankylosing spondylitis (AS) treated with the herbal medicine Tripterygium wilfordii Hook f (TwHf; lei gong teng, thunder god vine), w...
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Article
Expression and proteolytic activity of calpain in lens epithelial cells of oxidative cataract
Objective: To study the role of calpain in the mechanism of oxidative cataract through detecting the level of intracellular free Ca2+, the expression and proteolytic activity of calpain in the lens epithelial cel...
