18 Result(s)

Article

Roxadustat and Oral Iron Absorption in Chinese Patients with Anemia of Chronic Kidney Disease: A Randomized, Open-Label, Phase 4 Study (ALTAI)

Anemia of chronic kidney disease (CKD) has a high incidence and is associated with many disease conditions. Iron dysmetabolism is an important contributor to anemia in CKD patients.

Haiting Wu, Hong Cheng, Caili Wang, Li Yao, Shuguang Qin, Li Zuo… in Advances in Therapy (2024)

Article

Oral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension

In the event-driven FREEDOM-EV trial, oral treprostinil delayed clinical worsening in patients with pulmonary arterial hypertension (PAH). Open-label extension studies offer additional data about tolerability,...

Ekkehard Grünig, Franck Rahaghi, Jean Elwing, Carmine Dario Vizza… in Advances in Therapy (2024)

Article

Correction to: Effect of Nicorandil, Diltiazem, or Isosorbide Mononitrate for Oral Antispastic Therapy After Coronary Artery Bypass Grafting Using Radial Artery Grafts—A Pilot Randomized Controlled Trial (ASRAB-Pilot): Rationale and Study Protocol

Yunpeng Zhu, Kaijie Qin, Yun Liu, Haoyi Yao, Wei Zhang, Qiang Zhao in Advances in Therapy (2023)

Article

An EMT-Related Gene Signature to Predict the Prognosis of Triple-Negative Breast Cancer

Epithelial–mesenchymal transition (EMT) is an important biological process in tumor invasion and metastasis, and thus a potential indicator of the progression and drug resistance of breast cancer. This study c...

Bo Zhang, Rong Zhao, Qi Wang, Ya-**g Zhang, Liu Yang, Zhou-Jun Yuan… in Advances in Therapy (2023)

Article

The effect of rifampin on the pharmacokinetics of famitinib in healthy subjects

Famitinib is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor under clinical investigation for the treatment of solid tumors. As famitinib is metabolized mainly by cytochrome P450 3A4 (CYP3A4)...

Ting Li, **n Li, **n Jiang, Chen**g Wang… in Cancer Chemotherapy and Pharmacology (2022)

Article

Pulmonary granulomatous inflammation after ceritinib treatment in advanced ALK-rearranged pulmonary adenocarcinoma

Ceritinib is a new anaplastic lymphoma kinase (ALK) inhibitor that has shown greater potency in patients with advanced ALK-rearranged non-small cell lung cancer, including those who had disease progression in ...

Juanyan Liao, Hui Guan, Min Yu, ** Zhou, Yao Han… in Investigational New Drugs (2022)

Article

Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study

To assess early changes in serum histone H3 concentration in patients with urosepsis and its predictive ability for the onset of urosepsis.

**angcheng Zhan, Ding Liu, Yunze Dong, Yunchen Gao, **ao Xu… in Advances in Therapy (2022)

Article

Apatinib with doxorubicin and ifosfamide as neoadjuvant therapy for high-risk soft tissue sarcomas: a retrospective cohort study

There is a need to establish an effective neoadjuvant therapy for soft tissue sarcomas (STSs). We previously showed that apatinib, administered in combination with doxorubicin-based chemotherapy, improves the ...

Zhichao Tian, Jiaqiang Wang, **po Yang, Peng Zhang, **n Wang… in Investigational New Drugs (2021)

Article

Phase I/II study to assess the clinical pharmacology and safety of single ascending and multiple subcutaneous doses of PF-06881894 in women with non-distantly metastatic breast cancer

To evaluate the pharmacodynamics (PD), pharmacokinetics (PK), and safety of single and multiple doses of PF-06881894 (pegfilgrastim-apgf; Nyvepria^™), a biosimilar to reference pegfilgrastim (Neulasta^®), in women ...

Hsuan-Ming Yao, Sarah Ruta Jones, Serafin Morales… in Cancer Chemotherapy and Pharmacology (2021)

Article

Efficacy and Safety of Ciprofol Sedation in ICU Patients with Mechanical Ventilation: A Clinical Trial Study Protocol

From previous studies of pharmacodynamic data in mice, rats, beagle dogs and mini pigs, frequently in direct comparison to induction doses of propofol, ciprofol produced a rapid onset of anesthesia/sedation.

Yongjun Liu, Chuanxi Chen, Ning Liu, Li Tong, Yao Nie, Jianfeng Wu… in Advances in Therapy (2021)

Article

Retraction Note to: Aplysin enhances temozolomide sensitivity in glioma cells by increasing miR‑181 level

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s00280-020-04166-1.

An**g Gong, Na Ge, Weicheng Yao, Luxiang Lu… in Cancer Chemotherapy and Pharmacology (2021)

Article

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3–11 Years with Hepatitis C Genotype 1a

To assess the safety, efficacy, and pharmacokinetics of mini-tablet formulations of ombitasvir (OBV), paritaprevir (PTV), ritonavir, and dasabuvir (DSV) with or without ribavirin for 12 weeks in children infec...

Philip Rosenthal, Michael R. Narkewicz, Betty B. Yao… in Advances in Therapy (2020)

Article

PF-06881894, a Proposed Biosimilar to Pegfilgrastim, Versus US-Licensed and EU-Approved Pegfilgrastim Reference Products (Neulasta^®): Pharmacodynamics, Pharmacokinetics, Immunogenicity, and Safety of Single or Multiple Subcutaneous Doses in Healthy Volunteers

PF-06881894 is a proposed biosimilar to pegfilgrastim (Neulasta^®). This study evaluated the pharmacodynamic/pharmacokinetic (PD/PK) equivalence, immunogenicity, and safety of ...

Shahrzad Moosavi, Troy Borema, Reginald Ewesuedo, Stuart Harris… in Advances in Therapy (2020)

Article

Distinct Serum and Vitreous Inflammation-Related Factor Profiles in Patients with Proliferative Vitreoretinopathy

Proliferative vitreoretinopathy (PVR), which is regulated by growth factors and cytokines, is the leading cause of failure in vitreoretinal surgery. In this study, we aimed to investigate the role of the human...

Yao Ni, Yingyan Qin, Zi**g Huang, Fangyuan Liu, Shaochong Zhang… in Advances in Therapy (2020)

Article

Prolonged-Release (PR) Oxycodone/Naloxone Improves Bowel Function Compared with Oxycodone PR and Provides Effective Analgesia in Chinese Patients with Non-malignant Pain: A Randomized, Double-Blind Trial

Prolonged-release oxycodone/naloxone (OXN PR), combining an opioid analgesic with selective blockade of enteric µ-opioid receptors, provided effective analgesia and improved bowel function in patients with mod...

**aomei Leng, Fengxiao Zhang, Shanglong Yao, **sheng Weng, Kaizhi Lu… in Advances in Therapy (2020)

Article

Prevalence of Lower Urinary Tract Symptoms in China, Taiwan, and South Korea: Results from a Cross-Sectional, Population-Based Study

Few population-based data are available evaluating the prevalence of lower urinary tract symptoms (LUTS) in Asia. The objective of our study was to determine LUTS prevalence in China, Taiwan, and South Korea u...

Christopher Chapple, David Castro-Diaz, Yao-Chi Chuang, Kyu-Sung Lee… in Advances in Therapy (2017)

Article

FOXC1 overexpression is a marker of poor response to anthracycline-based adjuvant chemotherapy in sporadic triple-negative breast cancer

Because of its aggressive characteristics and poor prognosis, triple-negative breast cancer (TNBC) has become a hot topic in cancer research. Chemotherapy is currently the only treatment for patients with TNBC...

Y. L. Xu, R. Yao, J. Li, Y. D. Zhou, F. Mao, B. Pan… in Cancer Chemotherapy and Pharmacology (2017)

Article

Phase II study of bevacizumab and erlotinib in the treatment of advanced hepatocellular carcinoma patients with sorafenib-refractory disease

Background The combination of bevacizumab (B) and erlotinib (E) has shown promising clinical outcomes as the first-line treatment of advanced HCC patients. We aimed to evaluate the efficacy and s...

Thomas Yau, Hilda Wong, Pierre Chan, T. J. Yao, R. Pang… in Investigational New Drugs (2012)