150 Result(s)

Article

Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang… in Acta Pharmacologica Sinica (2024)

Article

HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...

Ya-juan Guo, **g-**g Yao, Zhen-zhen Guo, Ming Ding… in Acta Pharmacologica Sinica (2024)

Article

Retraction Note: Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 Cells

Qiang Su, Jun**g Yao, Cunjian Sheng in Inflammation (2024)

Article

Roxadustat and Oral Iron Absorption in Chinese Patients with Anemia of Chronic Kidney Disease: A Randomized, Open-Label, Phase 4 Study (ALTAI)

Anemia of chronic kidney disease (CKD) has a high incidence and is associated with many disease conditions. Iron dysmetabolism is an important contributor to anemia in CKD patients.

Haiting Wu, Hong Cheng, Caili Wang, Li Yao, Shuguang Qin, Li Zuo… in Advances in Therapy (2024)

Article

Oral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension

In the event-driven FREEDOM-EV trial, oral treprostinil delayed clinical worsening in patients with pulmonary arterial hypertension (PAH). Open-label extension studies offer additional data about tolerability,...

Ekkehard Grünig, Franck Rahaghi, Jean Elwing, Carmine Dario Vizza… in Advances in Therapy (2024)

Article

Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways

The FLT3/ITD mutation exists in many acute myeloid leukemia (AML) patients and is related to the poor prognosis of patients. In this study, we attempted to evaluate the antitumor activity of simvastatin, a member...

Genhong Li, **gwei Yao, Zhen Lu, Lian Yu, Qinwei Chen, Lihong Ding… in Drugs in R&D (2023)

Article

Correction to: Effect of Nicorandil, Diltiazem, or Isosorbide Mononitrate for Oral Antispastic Therapy After Coronary Artery Bypass Grafting Using Radial Artery Grafts—A Pilot Randomized Controlled Trial (ASRAB-Pilot): Rationale and Study Protocol

Yunpeng Zhu, Kaijie Qin, Yun Liu, Haoyi Yao, Wei Zhang, Qiang Zhao in Advances in Therapy (2023)

Article

An EMT-Related Gene Signature to Predict the Prognosis of Triple-Negative Breast Cancer

Epithelial–mesenchymal transition (EMT) is an important biological process in tumor invasion and metastasis, and thus a potential indicator of the progression and drug resistance of breast cancer. This study c...

Bo Zhang, Rong Zhao, Qi Wang, Ya-**g Zhang, Liu Yang, Zhou-Jun Yuan… in Advances in Therapy (2023)

Article

Correction to: Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study

Thomas Yen-Ting Chen, Shiow-Ing Wang, Yao-Min Hung, Joshua J. Hartman, Renin Chang… in Drugs (2023)

Article

Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules

Ebola virus (EBOV) causes hemorrhagic fever in humans with high morbidity and fatality. Although over 45 years have passed since the first EBOV outbreak, small molecule drugs are not yet available. Ebola viral...

Yan-hong Ma, Xu Hong, Fang Wu, **n-feng Xu, Rui Li, ** Zhong… in Acta Pharmacologica Sinica (2023)

Article

Pharmacokinetics and Bioequivalence of Abiraterone Acetate Tablets in Healthy Chinese Volunteers: An Open, Randomized, Single-Dose, Three-Period, Three-Sequence Crossover Study

Abiraterone acetate tablet is an inhibitor of androgen synthesis, primarily for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This study evaluated the bioequivalence and pharmacokin...

Zhao-xin Wu, Chen-**g Wang, ** Shi, Yan-** Liu, Ting Li, Fei-fei Sun… in Drugs in R&D (2023)

Article

Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study

To explore the association between human papillomavirus (HPV) vaccination and risk of coronavirus disease 2019 (COVID-19). Specifically, our study aimed to test the hypothesis that HPV vaccination may also ind...

Thomas Yen-Ting Chen, Shiow-Ing Wang, Yao-Min Hung, Joshua J. Hartman, Renin Chang… in Drugs (2023)

Article

Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease

Inflammation is one of the pathogenic processes in Parkinson’s disease (PD). Dopamine receptor agonist pramipexole (PPX) is extensively used for PD treatment in clinics. A number of studies show that PPX exert...

An-qi Dong, Ya-** Yang, Shu-min Jiang, **ao-yu Yao, Di Qi… in Acta Pharmacologica Sinica (2023)

Article

Author Correction: QAP14 suppresses stemness and metastasis of breast cancer via the activation of dopamine D1 receptor

Ling Yong, Ye Yao, Guo-shu Chen, **ao-xue Yan, Yu-chen Guo… in Acta Pharmacologica Sinica (2022)

Article

Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

The multi-generation heredity trait of hypertension in human has been reported, but the molecular mechanisms underlying multi-generational inheritance of hypertension remain obscure. Recent evidence shows that...

**ao Guan, Guo-rong Dan, Yao Yang, Yan Ji, Wen-**g Lai… in Acta Pharmacologica Sinica (2022)

Article

Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

An epidemic of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. SARS-CoV-2 relies on its spike protein to invade host cells by interacting with the human...

Lin Wang, Yan Wu, Sheng Yao, Huan Ge, Ya Zhu, Kun Chen… in Acta Pharmacologica Sinica (2022)

Article

Pharmacokinetics and Bioequivalence of Sitagliptin Phosphate/Metformin Hydrochloride Tablets in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Study

Our objective was to evaluate the pharmacokinetics and bioequivalence of test and reference (JANUMET^®) formulations of sitagliptin phosphate/metformin hydrochloride tablets at a single dose of 50 mg/850 mg.

** Shi, **n Liu, Ting Li, Fei-fei Sun, Yan-** Liu, Shu-qin Liu… in Drugs in R&D (2022)

Article

Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants

Urine is conventionally used as a specimen to document diazepam-related crimes; however, few reports have described the pharmacokinetics of diazepam and its metabolites in urine.

Le-le Wang, **n-xin Ren, Yi He, Guan-feng Cui, Jia-jia Liu, Juan Jia… in Drugs in R&D (2022)

Article

Early Changes and Predictive Value of Serum Histone H3 Concentration in Urosepsis: A Prospective Observational Study

To assess early changes in serum histone H3 concentration in patients with urosepsis and its predictive ability for the onset of urosepsis.

**angcheng Zhan, Ding Liu, Yunze Dong, Yunchen Gao, **ao Xu… in Advances in Therapy (2022)

Article

Efficacy and Safety of Ciprofol Sedation in ICU Patients with Mechanical Ventilation: A Clinical Trial Study Protocol

From previous studies of pharmacodynamic data in mice, rats, beagle dogs and mini pigs, frequently in direct comparison to induction doses of propofol, ciprofol produced a rapid onset of anesthesia/sedation.

Yongjun Liu, Chuanxi Chen, Ning Liu, Li Tong, Yao Nie, Jianfeng Wu… in Advances in Therapy (2021)