59 Result(s)

Article

Machine Learning Approach in Dosage Individualization of Isoniazid for Tuberculosis

Isoniazid is a first-line antituberculosis agent with high variability, which would profit from individualized dosing. Concentrations of isoniazid at 2 h (C_2h), as an indicator of safety and efficacy, are importa...

Bo-Hao Tang, **n-Fang Zhang, Shu-Meng Fu, Bu-Fan Yao… in Clinical Pharmacokinetics (2024)

Article

Development of a Physiologically Based Pharmacokinetic Population Model for Diabetic Patients and its Application to Understand Disease-drug–drug Interactions

The activity changes of cytochrome P450 (CYP450) enzymes, along with the complicated medication scenarios in diabetes mellitus (DM) patients, result in the unanticipated pharmacokinetics (PK), pharmacodynamics...

Yafen Li, **aonan Li, Miao Zhu, Huan Liu, Zihan Lei… in Clinical Pharmacokinetics (2024)

Article

Increased Nasal Blimp1 + Treg Cells After Sublingual Immunotherapy Reflect the Efficacy of Treatment in Allergic Rhinitis

Allergen-specific immunotherapy (AIT) plays a pivotal role in altering the immune status and tissue responses in allergic rhinitis (AR). This study focuses on the impact of sublingual immunotherapy (SLIT) invo...

Yue Pan, **nxin Zhang, Huanting Geng, Yan Yu, Jianyong Liu… in Advances in Therapy (2024)

Article

Artificial Intelligence in Liver Diseases: Recent Advances

Liver diseases cause a significant burden on public health worldwide. In spite of great advances during recent years, there are still many challenges in the diagnosis and treatment of liver diseases. During re...

Feifei Lu, Yao Meng, **aoting Song, **aotong Li, Zhuang Liu… in Advances in Therapy (2024)

Article

Reply to the Comments on “Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study”

Thomas Yen-Ting Chen, Qianru Zhang, Yao-Min Hung, Renin Chang, Shiow-Ing Wang… in Drugs (2024)

Article

Population Pharmacokinetic/Pharmacodynamic Analysis of the Glucokinase Activator PB201 in Healthy Volunteers and Patients with Type 2 Diabetes Mellitus: Facilitating the Clinical Development of PB201 in China

PB201 is an orally active, partial glucokinase activator targeting both pancreatic and hepatic glucokinase. As the second glucokinase activator studied beyond phase I, PB201 has demonstrated promising glycemic...

Ling Song, Fangrui Cao, Shu Niu, Michael Xu, Ruifang Liang… in Clinical Pharmacokinetics (2024)

Article

Efficacy and Safety of Different Doses of Rivaroxaban and Risk Factors for Bleeding in Elderly Patients with Venous Thromboembolism: A Real-World, Multicenter, Observational, Cohort Study

Venous thromboembolism (VTE) consists of deep vein thrombosis (DVT) and pulmonary embolism (PE). Rivaroxaban is a direct oral anticoagulant (DOAC) inhibiting activated coagulation factor X (FXa), and exerts se...

Kepeng Lu, Qian-Qian Liao, Ke-Wei Zhu, Ying Yao, **ao-Jiao Cui… in Advances in Therapy (2024)

Article

Genetic Evidence Supporting a Causal Association Between mTOR-Dependent EIF-4E Circulating Protein Level and Osteoporosis

The mechanistic target of rapamycin (mTOR) regulates bone homeostasis, a crucial factor in osteoporosis (OP) development. However, most research is based on observational studies, and the causality remains unc...

Ting Cheng, Yao-Chen Zhang, Ke-Yi Fan, **g-** Hu, Qian Wang… in Advances in Therapy (2023)

Article

Study on the Relationship Between Differentially Expressed Proteins in Breast Cancer and Lymph Node Metastasis

Lymph node metastasis is a cause of poor prognosis in breast cancer. Mass spectrometry-based proteomics aims to map the protein landscapes of biological samples and profile tumors more comprehensively. Here, p...

Yu-Lu Sun, Yi-**n Zhao, Yi-Nan Guan, **n You, Yin Zhang, Meng Zhang… in Advances in Therapy (2023)

Article

Effect of Nicorandil, Diltiazem, or Isosorbide Mononitrate for Oral Antispastic Therapy After Coronary Artery Bypass Grafting Using Radial Artery Grafts—A Pilot Randomized Controlled Trial (ASRAB-Pilot): Rationale and Study Protocol

The current evidence for chronic oral antispastic medication use after coronary artery bypass grafting using radial artery grafts (RA-CABG) is controversial. Calcium channel blockers, such as diltiazem, are th...

Yunpeng Zhu, Kaijie Qin, Yun Liu, Haoyi Yao, Wei Zhang, Qiang Zhao in Advances in Therapy (2023)

Article

Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates

High variability in vancomycin exposure in neonates requires advanced individualized dosing regimens. Achieving steady-state trough concentration (C₀) and steady-state area-under-curve (AUC_0–24) targets is import...

Bo-Hao Tang, **-Yuan Zhang, Karel Allegaert, Guo-**ang Hao… in Clinical Pharmacokinetics (2023)

Article

Study Protocol of a Multicenter, Randomized, Single-Blind Trial: Efficacy and Safety of Remimazolam Tosylate for Sedation in ICU Patients

Pharmacodynamic and pharmacokinetic studies in animal experiments and a phase 1 study suggested remimazolam tosylate as an effective and safe sedation/anesthetic agent. However, the effects and safety dose of ...

Ning Liu, Zhiyi Jiang, Yao Nie, Lingyun Zuo, Chuanxi Chen, **ang Si… in Advances in Therapy (2023)

Article

The Comparative Effectiveness and Safety of Insomnia Drugs: A Systematic Review and Network Meta-Analysis of 153 Randomized Trials

Pharmacological treatment is common in practice and widely used for the management of insomnia. However, evidence comparing the relative effectiveness, safety, and certainty of evidence among drug classes and ...

Bei Pan, Long Ge, Honghao Lai, Liangying Hou, Chen Tian, Qi Wang, Kelu Yang… in Drugs (2023)