-
Article
Open AccessNetwork-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis
Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-...
-
Article
Open AccessReciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. ...
-
Article
Open AccessPrognostic significance of liver stiffness in patients with primary biliary cholangitis: validation of Baveno VII criteria
The role of liver stiffness measurements (LSM) in patients with primary biliary cholangitis (PBC) remains to be further elucidated.
-
Article
Open AccessThe CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
CD8+ T cells play an important role in anti-tumor immunity. Better understanding of their regulation could advance cancer immunotherapies. Here we identify, via stepwise CRISPR-based screening, that CUL5 is a neg...
-
Article
Open AccessIdentifying optimal candidates for autologous peripheral blood stem cell therapy in patients with decompensated liver cirrhosis: a prognostic scoring system
Stem cell transplantation shows great potential to improve the long-term survival of cirrhosis patients. However, therapeutic effects may not be homogeneous across the whole study population. This study constr...
-
Article
Research and prospect of novel WC-HEA cemented carbide
With the rapid development of industrial manufacturing, traditional WC–Co cemented carbides have exposed more and more problems. Therefore, the preparation of ultrafine/nanocrystalline-grained cemented carbide...
-
Article
Open AccessAn optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
The serine/threonine kinase AKT is a central node in cell signaling. While aberrant AKT activation underlies the development of a variety of human diseases, how different patterns of AKT-dependent phosphorylat...
-
Article
Open AccessMesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages
Despite emerging evidence on the therapeutic potential of mesenchymal stem cells (MSCs) for liver fibrosis, the underlying mechanisms remain unclear. At present, MSC-derived exosomes (MSC-EXOs) are widely acce...
-
Article
A study of plasmon-driven catalytic 4-NBT to DMAB in the dry film by using spatial Raman map** spectroscopy
Plasmon-driven catalytic reaction (PDCR) as a part of photocatalysis has attracted immense attention. Due to the collective oscillation of free electrons at the surface of metallic nanostructures, the charge d...
-
Article
Open AccessComprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry
Human peripheral blood mononuclear cells (PBMCs) originate from hematopoietic stem cells in the bone marrow, which mainly includes lymphocytes (T cells, B cells, and natural killer cells) and monocytes. Cryopr...
-
Article
Open AccessIdentification and validation a costimulatory molecule gene signature to predict the prognosis and immunotherapy response for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Costimulatory molecules have been proven to be the foundation of immunotherapy. However, the potential roles of costimulatory mo...
-
Article
Open AccessMultiple solutions for singular semipositone boundary value problems of fourth-order differential systems with parameters
The aim of this paper is to establish some results about the existence of multiple solutions for the following singular semipositone boundary value problem of fourth-order differential systems with parameters: ...
-
Article
Open AccessClinical characteristics and treatment outcomes of acute severe autoimmune hepatitis
Acute severe autoimmune hepatitis (AS-AIH) is a rare cause of acute liver failure (ALF), which is often neglected and delayed in treatment. The purpose of this study was to analyze the clinical characteristics...
-
Article
Positive and negative solutions for the nonlinear fractional Kirchhoff equation in \({\mathbb {R}}^{N}\)
This paper is concerned with the following nonlinear fractional Kirchhoff equation $$\begin{aligned} (a+\lambda \int _{{\mathbb {R}}^{N}}|(-\varDelta )^{\frac{s}{2}}u|^{2}dx)(-\varDelta )^{s}u+V(x)u=f(x,u)+ w(x)...
-
Article
Graphitic-carbon nitride nanosheets as a new inorganic filler for improving energy storage density of PVDF-based dielectric composites
Graphitic-phase carbon nitride (g-C3N4) nanosheets with lateral size of 1000 nm, 500 nm, and 100 nm have been fabricated by a one-step thermal condensation method at different thermal treating temperatures and us...
-
Article
Open AccessStrategies to enable large-scale proteomics for reproducible research
Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass spectrometry (MS) over time and across instruments and de...
-
Article
A hybrid electrically-and-piezoelectrically driven micromixer built on paper for microfluids mixing
This study aims to explore the channel patterns and the characteristic parameters of the zigzag microchannel based on microfluidic paper-based analytical devices (μPADs), in which the mixing efficiency and spe...
-
Article
Amplification of terahertz/infrared field at the nodes of Ranvier for myelinated nerve
The myelination of axons was the last major evolution in the vertebrate nervous system. Myelin promotes the speed of action potential by two orders, and modulates the conduction of neurons, important for learn...
-
Article
Prediction of the Solubilities of Water in Hydrocarbons with COSMO-RS and Interpretation of the Solubility Characteristics
The solubilities of water in various hydrocarbons are usually needed to assess the water content in oil products. Because the solubilities of water in hydrocarbons are very small, which usually leads to large ...
-
Article
Spatial Raman map** investigation of SERS performance related to localized surface plasmons
In this research, it reported a novel three-dimensional (3D) metallic hybrid system by introducing single-layer graphene (SLG) between silver nanoparticles (NPs) and silver nano-discs (NDs) arrays (Ag NPs/SLG/...
