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Article
Expression of N-myristoyltransferase in Human Brain Tumors
N-myristoylation is a process of covalent irreversible protein modification that promotes association of proteins with membranes. Based on our previous findings of elevated N-myristoyltransferase (NMT) activit...
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Article
Regulation of N-myristoyltransferase by novel inhibitor proteins
N-myristoylation ensures the proper function and intracellular trafficking of proteins. Many proteins involved in a wide variety of signaling, including cellular transformation and oncoge...
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Article
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3′-untranslated regio...
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Article
Open AccessmiRNAs at the heart of the matter
Cardiovascular disease is among the main causes of morbidity and mortality in developed countries. The pathological process of the heart is associated with altered expression profile of genes that are importan...
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Article
Microstructural features and properties of high-hardness and heat-resistant dispersion strengthened copper by reaction milling
The oxide dispersion strengthened copper alloys are attractive due to their excellent combination of thermal and electrical conductivities, high-temperature strength and microstructure stability. To date, the ...
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Article
Open AccessOverexpression of M3 Muscarinic Receptor Is a Novel Strategy for Preventing Sudden Cardiac Death in Transgenic Mice
The present study was designed to investigate the cardiac benefits of M3 muscarinic receptor (M3-mAChR) overexpression and whether these effects are related to the regulation of the inward rectifying K+ channel b...
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Article
Correction: Corrigendum: The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
Nat. Med. 13, 486–497 (2007); published online 1 April 2007; corrected after print 6 December 2011 In the version of this article initially published, lanes from the original blot shown in Figure 2b (NIZ and I...
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Article
Addendum: The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
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Article
Open AccessBioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis
In folklore, some people take the decoction of Calyx seu Fructus Physalis (CSFP) for lowering blood lipids. The present study is designed to evaluate the lipid-lowering activities of CSFP, and search for its phar...
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Article
Homocysteine enhances clot-promoting activity of endothelial cells via phosphatidylserine externalization and microparticles formation
Total elevated plasma homocysteine (Hcy) is a risk factor for thromboembolism. Vascular endothelium is important to regulate coagulation, but the impact of Hcy on the clot-promoting activity (CPA) of endotheli...
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Article
Open AccessUpregulation of M3 muscarinic receptor inhibits cardiac hypertrophy induced by angiotensin II
M3 muscarinic acetylcholine receptor (M3-mAChR) is stably expressed in the myocardium, but its pathophysiological role remains largely undefined. This study aimed to investigate the role of M3-mAChR in cardiac hy...
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Article
Downregulation of miR-133 via MAPK/ERK signaling pathway involved in nicotine-induced cardiomyocyte apoptosis
Tobacco smoking is a risk factor for many diseases, and nicotine is a major component of tobacco. Our previous work revealed that nicotine can induce myocardial fibrosis. This study aimed to investigate whethe...
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Article
Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling
Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the ...
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Article
Open AccessReciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction
This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for acute myocardial infarction (AMI). We measured the circulating levels of 15 individual lncRNAs, known...
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Article
PtNi nanoparticles embedded in porous silica microspheres as highly active catalysts for p-nitrophenol hydrogenation to p-aminophenol
Supported Pt-based alloy nanoparticles have attracted greater attention in catalysis due to their high activity, reduced cost, and easy recycling in chemical reactions. In this work, mesoporous SiO2 microspheres ...
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Article
Open AccessMIAT Is a Pro-fibrotic Long Non-coding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium
A long non-coding RNA (lncRNA), named myocardial infarction associated transcript (MIAT), has been documented to confer risk of myocardial infarction (MI). The aim of this study is to elucidate the pathophysio...
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Article
Open AccessIsoprenaline/β2-AR activates Plexin-A1/VEGFR2 signals via VEGF secretion in gastric cancer cells to promote tumor angiogenesis
The role of stress signals in regulating gastric cancer initiation and progression is not quite clear. It is known that stress signals modulate multiple processes such as immune function, cell migration and an...
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Article
Open AccessLong non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
Long non-coding RNAs (lncRNAs) have emerged as a new class of gene expression regulators playing key roles in many biological and pathophysiological processes. Here, we identify cardiac conduction regulatory R...
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Article
YAP1/Twist promotes fibroblast activation and lung fibrosis that conferred by miR-15a loss in IPF
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic parenchymal lung disease of unknown etiology and lack effective interventions. Using a combination of in vitro and in vivo studies, we fo...
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Chapter and Conference Paper
Study on Properties of Polyurethane Grouting Foam Material for High-Speed Railway Track Lifting
In this paper, a novel polyurethane grouting foam materials (PGFM) were optimized with the polyether polyol species, molecular weight, functional degree, isocyanate index, chain extender contents, catalyst spe...
