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  1. Article

    Open Access

    EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death

    TNF acts as one pathogenic driver for inducing intestinal epithelial cell (IEC) death and substantial intestinal inflammation. How the IEC death is regulated to physiologically prevent intestinal inflammation ...

    Jiacheng Wu, **aoqing Xu, Jiaqi Duan, Yangyang Chai, Jiaying Song in Nature Communications (2024)

  2. Article

    Open Access

    BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage1. The receptor binding and immune-evasion capability...

    Yunlong Cao, Ayijiang Yisimayi, Fanchong Jian, Weiliang Song, Tianhe **ao in Nature (2022)

  3. Article

    Open Access

    iTRAQ-Based Quantitative Proteomic Analysis of the Inhibitory Effects of Polysaccharides from Viscum coloratum (Kom.) Nakai on HepG2 Cells

    Viscum coloratum (Kom.) Nakai is one of active medicinal plants, and its active components, especially polysaccharides, have been shown to exhibit bioactivity. In this study, we examined ...

    Yangyang Chai, Min Zhao in Scientific Reports (2017)

  4. Article

    Open Access

    A proteomic analysis of mushroom polysaccharide-treated HepG2 cells

    The anti-tumor properties of fungal polysaccharides have gained significant recognition in Asia and tropical America. In this study, the differential expression of proteins in normal HepG2 cells and those trea...

    Yangyang Chai, Guibin Wang, Lili Fan, Min Zhao in Scientific Reports (2016)