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  1. Article

    Open Access

    The mechanism of action and experimental verification of Gan-song Yin on renal clear cell carcinoma based on network pharmacology and bioinformatics

    Gan-song Yin (GSY) is originated from the scripture “Gan-song Pills”, a medical work of the Ningxia ethnic minorities, and its treatment of kidney diseases has good results. Its method of treating Renal clear ...

    Wenjie Jiang, Ling Yuan, Qian Liu, **angyang Li, Yifan Yang in Discover Oncology (2024)

  2. Article

    Open Access

    Hip circumference has independent association with the risk of hyperuricemia in middle-aged but not in older male patients with type 2 diabetes mellitus

    Obesity and type 2 diabetes mellitus (T2DM) are risk factors for hyperuricemia. However, which anthropometric indices can better predict incident hyperuricemia in patients with T2DM remains inconsistent. This ...

    Wenyi Lu, Xuan Zhao, **ye Sheng, Xuelin Zhao, Qingya Tang in Nutrition Journal (2023)

  3. Article

    Open Access

    Mediating role of depressive symptoms on the relationship between sleep duration and cognitive function

    Although some studies have shown the association between sleep duration and cognitive impairment is positive, the mechanism explaining how sleep duration is linked to cognition remains poor understood. The cur...

    Liqun Wang, Shulan He, Ning Yan, Rui** Pan, Yang Niu, Jiang** Li in Scientific Reports (2023)

  4. No Access

    Chapter

    Roles of Phosphatidylinositol 4-Phosphorylation in Non-vesicular Cholesterol Trafficking

    (Chol) is an essential component of all eukaryotic cell membranes that affects the function of numerous peripheral as well as integral membrane proteins. Chol is synthesized in the ER, but it is selectively e...

    Tamas Balla, Gergo Gulyas, Amrita Mandal in Cholesterol and PI(4,5)P2 in Vital Biologi… (2023)

  5. No Access

    Article

    LIPO: Indoor position and orientation estimation via superposed reflected light

    Owing to the widespread use of LED lighting and multipath-free propagation, light-to-camera communications (LCC) hold potential in the deployment of ubiquitous, robust, and accurate indoor positioning systems....

    Fan Yang, Shining Li, Hongbang Zhang, Yang Niu in Personal and Ubiquitous Computing (2022)

  6. Article

    Open Access

    Modified donor blood flow-preserved cross-leg anterolateral thigh flap procedure for complex lower extremity reconstruction

    Complex lower limb reconstruction due to severe trauma remains a challenge for reconstructive surgeons. Here, we introduce a modified donor blood flow-preserved cross-leg anterolateral thigh flap procedure and...

    Hong-**ang Zhou, Liang He, Dong Yin in Journal of Orthopaedic Surgery and Research (2022)

  7. Article

    Open Access

    MSC secreted extracellular vesicles carrying TGF-beta upregulate Smad 6 expression and promote the regrowth of neurons in spinal cord injured rats

    Mesenchymal stem cells (MSCs) constitute a promising therapy for spinal cord injury (SCI) because they can provide a favorable environment for the regrowth of neurons by inhibiting receptor-regulated Smads (R-...

    Tianyu Han, Peiwen Song, Zuomeng Wu, **a **ang, Yunlei Liu in Stem Cell Reviews and Reports (2022)

  8. Article

    Correction to: Piperine-Loaded Glycyrrhizic Acid- and PLGA-Based Nanoparticles Modified with Transferrin for Antitumor

    Shuang Li, Jueshuo Guo, Zonghua Tian, **g Chen, Guo**g Gou, Yang Niu in AAPS PharmSciTech (2021)

  9. No Access

    Article

    Piperine-Loaded Glycyrrhizic Acid- and PLGA-Based Nanoparticles Modified with Transferrin for Antitumor

    The purpose of this study was to enhance the antitumor effect of piperine by constructing the nanoparticles modified with transferrin (Tf-PIP-NPs) and evaluating their efficacy in vitro and in vivo. The Tf-PIP-NP...

    Shuang Li, Jueshuo Guo, Zonghua Tian, **g Chen, Guo**g Gou, Yang Niu in AAPS PharmSciTech (2021)

  10. Article

    Open Access

    Uric acid is associated with adiposity factors, especially with fat mass reduction during weight loss in obese children and adolescents

    Current adult studies suggest that uric acid (UA) is associated with body fat, but the relationship in obese children is unclear. Thus, we aim to evaluate the association between uric acid and body composition...

    Yang Niu, Xue-lin Zhao, Hui-juan Ruan, **ao-meng Mao in Nutrition & Metabolism (2020)

  11. Article

    Open Access

    The role of hepatocyte growth factor in mesenchymal stem cell-induced recovery in spinal cord injured rats

    Mesenchymal stem cells (MSCs) have become a promising treatment for spinal cord injury (SCI) due to the fact that they provide a favorable environment. Treatment using MSCs results in a better neurological fun...

    Peiwen Song, Tianyu Han, **a **ang, Ying Wang, Huang Fang in Stem Cell Research & Therapy (2020)

  12. Article

    Open Access

    Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism

    Lipopolysaccharides (LPS) of Gram-negative bacteria are critical for the defence against cytotoxic substances and must be transported from the inner membrane (IM) to the outer membrane (OM) through a bridge fo...

    **aodi Tang, Shenghai Chang, Qinghua Luo, Zhengyu Zhang, Wen Qiao in Nature Communications (2019)

  13. No Access

    Article

    Biochemical characterization of acyl-coenzyme A synthetases involved in mycobacterial steroid side-chain catabolism and molecular design: synthesis of an anti-mycobacterial agent

    The metabolism of host cholesterol by Mycobacterium tuberculosis is an important factor for both its virulence and pathogenesis. However, the rationale for this cholesterol metabolism has not been fully understoo...

    Yang Niu, Fanglan Ge, Yongzhi Yang, Yao Ren, Wei Li, Guiying Chen, Dongmei Wen in 3 Biotech (2019)

  14. No Access

    Article

    Lycium barbarum polysaccharide attenuates diabetic testicular dysfunction via inhibition of the PI3K/Akt pathway-mediated abnormal autophagy in male mice

    Testicular dysfunction is one of the serious secondary complications in diabetes. Lycium barbarum polysaccharide (LBP) has long been considered to possess a wide range of beneficial properties including antiaging...

    Guang-Jiang Shi, Jie Zheng, **ao-Xu Han, Ya-** Jiang in Cell and Tissue Research (2018)

  15. No Access

    Article

    Neuroprotection of Cytisine Against Cerebral Ischemia–Reperfusion Injury in Mice by Regulating NR2B-ERK/CREB Signal Pathway

    The aim of the study was to elucidate the therapeutic effects of Cytisine (CYT) on cerebral ischemia–reperfusion injury in mice. Male ICR mice were pretreated with reagents (drug), and then subjected to 2 h fo...

    Peng Zhao, Jia-Mei Yang, Yong-Sheng Wang, Yin-Ju Hao, Yu-**ang Li in Neurochemical Research (2018)

  16. No Access

    Article

    Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen–Glucose Deprivation and Reperfusion

    Oxysophocarpine (OSC), an alkaloid isolated from Sophora flavescens Ait, has been traditionally used as a medicinal agent based on the observed pharmacological effects. In this study, the direct effect of OSC ...

    Peng Zhao, Ren-Yuan Chang, Ning Liu, **g Wang in Cellular and Molecular Neurobiology (2018)

  17. No Access

    Article

    Neuroprotective Effect of Chitosan Oligosaccharide on Hypoxic-Ischemic Brain Damage in Neonatal Rats

    Neonatal hypoxic-ischemic brain damage (HIBD) is one of the leading causes of neonatal mortality and permanent neurological disability worldwide and the effective treatment strategies are not yet available. It...

    Wei Wu, Wei Wei, Min Lu, **aoyun Zhu, Ning Liu, Yang Niu, Tao Sun in Neurochemical Research (2017)

  18. No Access

    Article

    Anticonvulsant Effect of Swertiamarin Against Pilocarpine-Induced Seizures in Adult Male Mice

    Epilepsy is one of the common and major neurological disorders, approximately a third of the individuals with epilepsy suffer from seizures and not able to successfully respond to available medications. Curren...

    **an-Hua Deng, **ao Zhang, **g Wang, Peng-Sheng Ma, Lin Ma in Neurochemical Research (2017)

  19. No Access

    Article

    Neuroprotective Effects of Lycium barbarum Polysaccharide on Focal Cerebral Ischemic Injury in Mice

    Increasing evidence demonstrates inflammation contributes to neuronal death following cerebral ischemia. Lycium barbarum polysaccharide (LBP) has been reported to prevent scopolamine-induced cognitive and memory ...

    Peng Zhao, Ru Zhou, **ao-Yun Zhu, Gang Liu, Yu-** Zhao in Neurochemical Research (2017)

  20. No Access

    Article

    Mechanism of Lycium barbarum polysaccharides on primary cultured rat hippocampal neurons

    Lycium barbarum polysaccharides (LBP) have been reported to have a wide range of beneficial effects including neuroprotection, anti-aging and anticancer. However, the anti-inflammation me...

    Peng Zhao, Ning-Tian Ma, Ren-Yuan Chang, Yu-**ang Li in Cell and Tissue Research (2017)

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