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Article
Open AccessExosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer
Breast cancer is the most common malignant tumor, and metastasis remains the major cause of poor prognosis. Glucose metabolic reprogramming is one of the prominent hallmarks in cancer, providing nutrients and ...
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Article
COL5A1 promotes triple-negative breast cancer progression by activating tumor cell-macrophage crosstalk
Triple-negative breast cancer (TNBC) is an exceptionally aggressive subtype of breast cancer. Despite the recognized interplay between tumors and tumor-associated macrophages in fostering drug resistance and d...
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Article
Open AccessCircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation
Peptides and proteins encoded by noncanonical open reading frames (ORFs) of circRNAs have recently been recognized to play important roles in disease progression, but the biological functions and mechanisms of...
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Article
LncRNA PRBC induces autophagy to promote breast cancer progression through modulating PABPC1-mediated mRNA stabilization
Breast cancer is one of the major malignant tumors among women worldwide. Long noncoding RNAs (lncRNAs) have been documented as significant modulators in the development and progression of various cancers; how...
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Article
Open AccessEffects of game-based physical education program on enjoyment in children and adolescents: a systematic review and meta-analysis
The objective of this study was to conduct a systematic review to summarize and assess the advancements lately made on the enjoyable impacts of game-based physical education interventions on children and adole...
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Chapter and Conference Paper
LNMER-Net: A Metabolically Enhanced Lymph Node Metastasis Recognition Model Based on Lung Lymph Nodes and Microenvironment
PET/CT is the preferred device for lung cancer and lymph node metastasis diagnosis, and mining effective features from PET/CT images to identify lung lymph node metastasis has important research significance a...
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Chapter
The Confucian Argument for Equal Human Dignity
Human dignity is a crucial concept in contemporary ethical, political and legal studies. Protecting human dignity is a core value in modern human life. However, people have different, even opposite understandi...
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Article
Open AccessPTPRH promotes the progression of non-small cell lung cancer via glycolysis mediated by the PI3K/AKT/mTOR signaling pathway
The protein tyrosine phosphatase H receptor (PTPRH) is known to regulate the occurrence and development of pancreatic and colorectal cancer. However, its association with glycolysis in non-small cell lung canc...
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Article
Open AccessCross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history
After the eradication of smallpox in China in 1979, vaccination with the vaccinia virus (VACV) Tiantan strain for the general population was stopped in 1980. As the monkeypox virus (MPXV) is rapidly spreading ...
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Article
Open AccessLong non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with higher aggressiveness and poorer outcomes. Recently, long non-coding RNAs (lncRNAs) have become the crucial gene regulators in the progre...
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Article
Open AccessHypoxia-induced ALDH3A1 promotes the proliferation of non-small-cell lung cancer by regulating energy metabolism reprogramming
Aldehyde dehydrogenase 3A1 (ALDH3A1) is an NAD+-dependent enzyme that is closely related to tumor development. However, its role in non-small-cell lung cancer (NSCLC) has not been elucidated. This study aimed to ...
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Article
Open AccessDFT studies of solvent effect in hydrogen abstraction reactions from different allyl-type monomers with benzoyl radical
Inert allyl-type monomers have been widely documented due to reduce degradation chain transfer. Recently, we and others discovered that the [3 + 2] cyclization reaction process by a photo-driven radical reacti...
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Article
Open AccesscircRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells
Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in patients with estrogen receptor-positive (ER+) breast cancer. Thus, identifying novel ERα regulators is necessary to full...
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Article
Open AccessCancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication
Breast cancer is the major common malignancy worldwide among women. Previous studies reported that cancer-associated fibroblasts (CAFs) showed pivotal roles in regulating tumor progression via exosome-mediated...
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Article
Open AccessHSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer
Chemoresistance is one of the major causes of therapeutic failure and poor prognosis for breast cancer patients, especially for triple-negative breast cancer patients. However, the underlying mechanism remains...
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Article
Racial and Ethnic Disparities in Synchronous and Metachronous Bilateral Breast Cancer
Significant racial and ethnic disparities exist in breast cancer treatment and survival. However, studies characterizing these disparities among patients develo** bilateral breast cancers (BBC) are lacking. ...
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Article
Using gray level co-occurrence matrix texture features extracted from dual time point PET/CT images to diagnose malignant FDG-avid solitary pulmonary nodules
To determine whether gray level co-occurrence matrix (GLCM)-based texture features extracted from dual time point PET images (DTPI) can be used as a quantitative index to diagnose malignant FDG-avid solitary p...
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Article
Are there differences in outcomes by race among women with metastatic triple-negative breast cancer?
Black women have higher breast cancer mortality rates than other groups, with Triple-negative breast cancer (TNBC) being more common among AAs with a worse prognosis. Our study seeks to explore differences amo...
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Article
Open AccessCirc-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis
Numerous studies have shown that circRNAs are aberrantly expressed in various cancers and play a significant role in tumor progression. However, the molecular mechanisms of circRNAs in triple-negative breast c...
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Article
Open AccessAn ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope
New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a re...
