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Article
Open AccessS1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway
Cell senescence deters the activation of various oncogenes. Induction of senescence is, therefore, a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate rec...
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Article
Open AccessTanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis
Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathic disease associated with the anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions primarily located on t...
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Article
Open AccessEffects of 1,8-cineole on neuropathic pain mediated by P2X2 receptor in the spinal cord dorsal horn
As an intractable health threat, neuropathic pain is now a key problem in clinical therapy, which can be caused by lesions affecting the peripheral nervous systems. 1,8-cineole is a natural monoterpene cyclic ...
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Article
Biosensor of alkaline phosphatase based on non-fluorescent FRET of Eu3+-doped oxide nanoparticles and phosphorylated peptide labeled with cyanine dye
Dephosphorylation of biomolecules under the catalysis of alkaline phosphatase (ALP) is a critical physiological process. Abnormal levels of ALP activity have been associated with a number of diseases; thus, a ...
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Article
Microwave-assisted Synthesis and antifungal activity of coumarin[8,7-e][1,3]oxazine derivatives
The synthesis of novel coumarin[8,7-e][1,3]oxazine derivatives through a microwave-assisted three-component one-pot Mannich reaction is described in this study. All the target compounds were evaluated in vitro fo...
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Article
First-Principles Study the Electronic and Thermodynamic Properties for CoBi3 Superconductor
The electronic, elastic, and thermodynamic properties of CoBi3 superconductor are investigated by means of first-principles calculations along with the quasi-harmonic Debye model. Our results reveal that the calc...
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Article
SYNTHESIS BIODISTRIBUTION AND QSAR STUDIES OF FIVE Tc-99M LABELED NOVEL N3S PSEUDO-PEPTIDE COMPLEXES
Five novel N3S pseudo-peptide chelators derived from mercaptoacetic acid have been synthesized and characterized based on the spectroscopic data. All the chelators were labeled with Technicium-99m to evaluate ...