98 Result(s)
within
Ya-**ong Guo
Biomedicine, general
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Article
Effective tumor vaccines generated by in vitro modification of tumor cells with cytokines and bispecific monoclonal antibodies
Antitumor immune responses are mediated primarily by T cells1. Downregulation of the major histocompatiblity complex (MHC) and the molecules that costimulate the immune response is associated with defective signa...
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Article
Changed cellular membrane lipid composition and lipid peroxidation of kidney in rats with chronic fluorosis
An animal model of chronic fluorosis was produced by subjecting Wistar rats to high doses of fluoride in drinking water for a prolonged period. Phospholipid and neutral lipid contents in rat kidney were then ...
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Article
A20 overexpression under control of mouse osteocalcin promoter in MC3T3-E1 cells inhibited tumor necrosis factor-alpha-induced apoptosis
To construct an A20 expression vector under the control of mouse osteocalcin promoter (OC-A20), and investigate osteoblastic MC3T3-E1 cell line, which stably overexpresses A20 protein prevented tumor necrosis ...
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Article
A new mutation (1062 del 16) of iduronate-2-sulfatase gene from a Chinese patient with hunter syndrome
To identify the mutations of iduronate-2-sulfatase (IDS) gene, to reveal its mutation features, and to establish a basis for genetic counseling and prenatal gene diagnosis of Hunter syndrome.
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Article
Sodium butyrate-induced death-associated protein kinase expression promote Raji cell morphological change and apoptosis by reducing FAK protein levels
To investigate the role of death-associated protein kinase (DAPK) on the apoptosis of Raji cells induced by sodium butyrate.
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Article
Knock down of gfp and no tail expression in zebrafish embryo by in vivo-transcribed short hairpin RNA with T7 plasmid system
A short-hairpin RNA (shRNA) expression system, based on T7 RNA polymerase (T7RP) directed transcription machinery, has been developed and used to generate a knock down effect in zebrafish embryos by targeting gre...
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Article
Pharmacokinetic and pharmacodynamic study of LFA3Ig fusion protein in healthy volunteers and patients with psoriasis
To evaluate the pharmacokinetics (PK) and pharmacodynamics of the LFA3Ig fusion protein (LFA3IgFP) in healthy volunteers and patients with chronic plaque psoriasis.
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Article
Different Na+K+-ATPase signal pathways was involved in the increase of [Ca2+]i induced by strophanthidin in normal and failing isolated guinea pig ventricular myocytes
To determine whether different Na+/K+ -ATPase signal transduction pathways have positive inotropic effects on normal ventricular myocytes (NC) and failing ventricular myocytes (FC), and are involved in an increas...
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Article
Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis
To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA).
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Article
Open AccessCooperation of decay-accelerating factor and membrane cofactor protein in regulating survival of human cervical cancer cells
Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts the action of complement at critical stages o...
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Article
Characterization of a monomeric heat-labile classical alkaline phosphatase from Anabaena sp. PCC7120
Alkaline phosphatases (APs), known inducible enzymes of the Pho regulon and poorly characterized in cyanobacteria, hydrolyze phosphomonoesters to produce inorganic phosphate (Pi) during Pi starvation. In this stu...
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Article
Open AccessRole of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes
Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D2 receptors are expressed in cardiac tissues. However, the roles of dopamine D2 receptor...
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Article
The Arabidopsis lyrata genome sequence and the basis of rapid genome size change
Detlef Weigel and colleagues report the genome sequence of Arabidopsis lyrata. In comparison with the much smaller genome of A. thaliana, from which A. lyrata diverged about 10 million years ago, they find that t...
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Article
Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia
Zhi-Ying Wu and colleagues report the identification of truncating mutations in the PRRT2 gene in families with paroxysmal kinesigenic dyskinesia. PRRT2 encodes the proline-rich transmembrane protein 2.
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Article
Sociodemographic characteristics and risk factor analysis of Demodex infestation (Acari: Demodicidae)
To identify sociodemographic characteristics and risk factor of Demodex infestation, 756 students aged 13–22 years in **’an, China were sampled for the school-based cross-sectional study. Demodex was examined usi...
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Article
Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells
Due to their toxicity, the increased distribution of microcystins (MCs) has become an important worldwide problem. MCs have been recognized as inhibitors of protein phosphatase 2A (PP2A) through their binding ...
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Article
Tolerability, pharmacokinetics and pharmacodynamics of CMAB001, an anti-CD11a antibody, in Chinese healthy volunteers and psoriatic patients
To evaluate the pharmacokinetics (PK), pharmacodynamics (PD) and primary tolerability of an anti-CD11a monoclonal antibody (CMAB001) in Chinese healthy volunteers and psoriatic patients.
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Article
The dual role of osteopontin in acetaminophen hepatotoxicity
Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity...
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Article
Open AccessEffect of Bizhongxiao decoction and its dismantled formulae on IL-1 and TNF levels in collagen-induced arthritis in rat synovial joints
Rheumatoid arthritis (RA), a chronic autoimmune disease, affects sufferers in many different ways. Treatment of this chronic condition is particularly challenging. Traditional Chinese Medicine (TCM) provides a...
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Article
Volatile profile analysis and quality prediction of Long**g tea (Camellia sinensis) by HS-SPME/GC-MS
This study aimed to analyze the volatile chemical profile of Long**g tea, and further develop a prediction model for aroma quality of Long**g tea based on potent odorants. A total of 21 Long**g samples were...
