10 Result(s)
within
Ya Nan Zhang
Cell Biology
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Article
Open AccessAn alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant
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Open AccessDifferent pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters
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Open AccessIntranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice
The lung is the prophylaxis target against SARS-CoV-2 infection, and neutralizing antibodies are a leading class of biological products against various infectious viral pathogen. In this study, we develop a sa...
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Article
Open AccessIncreased morbidity of obese mice infected with mouse-adapted SARS-CoV-2
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Open AccessACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
The evolution of coronaviruses, such as SARS-CoV-2, makes broad-spectrum coronavirus preventional or therapeutical strategies highly sought after. Here we report a human angiotensin-converting enzyme 2 (ACE2)-...
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Open AccessA mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles
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Open AccessA cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2
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Effect of Interaction between Adenosine and Nitric Oxide on Central Nervous System Oxygen Toxicity
The metabolism of adenosine (ADO) and nitric oxide (NO) in brain tissues is closely associated with the change of oxygen content. They have contrary effects in the onset of hyperbaric oxygen (HBO)-induced cent...
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Open AccessThe inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer
Paclitaxel is widely used as a first-line chemotherapeutic drug for patients with ovarian cancer and other solid cancers, but drug resistance occurs frequently, resulting in ovarian cancer still presenting as ...
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Article
Defects in cytoskeletal microtubule deployment of microsporocytes contribute to fertility loss in genic male-sterile Chinese cabbage
The microtubular cytoskeleton of male-sterile Chinese cabbage was examined to characterize cytoplasmically based defects during microsporogenesis of fertile and sterile microsporocytes. At the onset of meiosis...
