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  1. Article

    Open Access

    Basal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection

    As most cases of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have concurrent cirrhosis, viral factors identified to be associated with HCC might be related to cirrhosis rather than HCC.

    C-M Chu, C-C Lin, Y-C Chen, W-J Jeng, S-M Lin, Y-F Liaw in British Journal of Cancer (2012)

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  2. No Access

    Article

    Does increased body mass index with hepatic steatosis contribute to seroclearance of hepatitis B virus (HBV) surface antigen in chronic HBV infection?

    Overweight and hepatic steatosis have been increasingly recognized recently. This study aimed to test whether substantial amount of fatty infiltration in liver, which may interfere with cytoplasmic distributio...

    C-M Chu, D-Y Lin, Y-F Liaw in International Journal of Obesity (2007)

  3. No Access

    Article

    Localization of a susceptibility locus for hepatocellular carcinoma to chromosome 4q in a hepatitis B hyperendemic area

    Chromosome 4q is one of the most common regions with a high frequency of allelic loss in hepatocellular carcinoma (HCC). To identify the HCC-susceptibility locus on chromosome 4q, we have performed linkage and...

    W-L Shih, M-W Yu, P-J Chen, S-H Yeh, M-T Lo, H-C Chang, Y-F Liaw, S-M Lin… in Oncogene (2006)

  4. No Access

    Article

    Increased Incidence of Fulminant Hepatic Failure in Previously Unrecognized HBsAg Carriers with Acute Hepatitis Independent of Etiology

    Previous studies have shown a high risk of fulminant hepatitis in HBsAg carriers with acute hepatitis. The etiology of acute hepatitis in HBsAg carriers was heterogeneous. This study aimed to correlate the inc...

    C. M. Chu, Y. F. Liaw in Infection (2005)

  5. No Access

    Article

    Sequential Changes of Hepatitis C Virus Antibody Profiles during Treatment of Chronic Hepatitis C of Genotype 1b: Pretreatment Antibody Response to E2/NS1 Correlated Sustained Response

    This study aimed to investigate the relation between hepatitis C virus (HCV) antibody profiles and response to therapy of chronic HCV infection of genotype 1b.

    C. M. Chu, I. S. Sheen, Y. F. Liaw in Infection (2004)

  6. Article

    Open Access

    Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells

    The gene of caspase-activated DNase (CAD), the key enzyme for nucleosome cleavage during apoptosis, is mapped at chromosome 1p36, a region usually associated with hemizygous deletions in human cancers, particu...

    S Y Hsieh, S F Liaw, S N Lee, P S Hsieh, K H Lin, C M Chu… in British Journal of Cancer (2003)

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  7. No Access

    Article

    Reactivation of Hepatitis C Virus Superinfection in a Patient Seropositive for Hepatitis B e Antigen

    L.-W. Chen, C.-T. Yeh, K.-M. Fang, C.-M. Chu, Y.-F. Liaw in Infection (2001)

  8. Article

    Open Access

    Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers

    Cigarette smoking has been associated with increased risk of hepatocellular carcinoma (HCC) in some epidemiological studies. Cytochrome P450 1A1 (CYP1A1) is involved in the biotransformation of tobacco-derived...

    M-W Yu, Y-H Chiu, S-Y Yang, R M Santella, H-D Chern, Y-F Liaw… in British Journal of Cancer (1999)

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  9. No Access

    Article

    Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22

    Both of hepatitis B virus core protein and a precore protein derivative, named P22, have been shown to localize in the nucleus. Although P22 has ten additional amino acid residues at its amino-terminus, both p...

    C. -T. Yeh, L. -H. Hong, J. -H. Ou, C. -M. Chu, Y. -F. Liaw in Archives of Virology (1996)

  10. No Access

    Article

    Clinicopathological response of HBsAg-positive chronic active hepatitis to adenine arabinoside: Lack of correlation with DNA polymerase response

    Fifteen patients with HBsAg-positive, severe chronic active heptatitis, nine DNA polymerase (DNAP)-positive and six negative were treated with intravenous adenine arabinoside (Ara-A) in a dose of 10 mg/kg/day ...

    Y. F. Liaw, D. Y. Lin M. D., C. M. Chu M. D., I. S. Sheen M. D.… in Infection (1984)