24 Result(s)
within
Y. le Marchand-Brustel
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Chapter
Impact des cytokines pro-inflammatoires sur la signalisation insulinique de l’adipocyte
Au cours de l’obésité, l’inflammation métabolique qui se développe dans le tissu adipeux (TA) va conduire à la production de cytokines inflammatoires (Chapitre Inflammation du tissu adipeux au cours de l’obési...
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Article
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity
Extracellular signal-regulated kinase (ERK) activity is increased in adipose tissue in obesity and type 2 diabetes mellitus and strong evidences suggests that it is implicated in the downregulation of insulin ...
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Article
Involvement of TNF-α in abnormal adipocyte and muscle sortilin expression in obese mice and humans
Insulin resistance is caused by numerous factors including inflammation. It is characterised by defective insulin stimulation of adipocyte and muscle glucose transport, which requires the glucose transporter G...
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Article
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
Metformin is a widely used antidiabetic agent, which regulates glucose homeostasis through inhibition of liver glucose production and an increase in muscle glucose uptake. Recent studies suggest that metformin...
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Article
Obésité et cancers du côlon et de la prostate: implication des adipokines
L’obésité est associée à de nombreuses pathologies comme le diabète et les maladies cardiovasculaires. Plus récemment, il a été montré que l’incidence de certains cancers est accrue chez les personnes obèses e...
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Article
Objectifs de l’AFERO: pour une médecine de l’obésité à la française
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Article
Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress
Induction of stress kinases leading to serine hyperphosphorylation of IRS1 may link oxidative stress to insulin resistance. The aim of this study was to investigate the roles of the phosphorylated serine resid...
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Article
Correction: Corrigendum: The lipid phosphatase SHIP2 controls insulin sensitivity
Nature 409, 92–96 (2001). In this Letter, we investigated the production and the phenotypic characterization of a SHIP2 (SH2 domain containing inositol phosphate 5-phosphatase type 2, or Inppl1) knockout mice....
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Article
MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632
Insulin-induced IRS-1 serine phosphorylation could be physiologically important to regulate insulin action. In a hyperinsulinaemic state such as obesity or Type 2 diabetes, this phosphorylation could be modifi...
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Article
GTPase activating protein activity for Rab4 is enriched in the plasma membrane of 3T3-L1 adipocytes. Possible involvement in the regulation of Rab4 subcellular localization
The small guanosine 5′-triphosphate (GTP)ase Rab4 has been suggested to play a role in insulin-induced GLUT4 translocation. Under insulin stimulation, GLUT4 translocates to the plasma membranes, while Rab4 lea...
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Article
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes
Insulin-induced glucose transport stimulation, which results from the translocation of glucose transporter 4 (GLUT 4)-containing vesicles, is completely blocked after prolonged insulin treatment of 3T3-L1 adip...
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Article
Autoantibodies to the insulin receptor are infrequent findings in Type 1 (insulin-dependent) diabetes mellitus of recent onset
To determine whether autoantibodies to the insulin receptor may represent markers of Type 1 (insulin-dependent) diabetes, the prevalence of such antibodies was investigated in sera of 60 newly diagnosed untrea...
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Article
Effect of an α-glycosidase inhibitor on experimentally-induced obesity in mice
The effect of prolonged treatment with acarbose, an inhibitor of α-glycosidase, has been studied in mice made obese and hyperinsulinaemic by goldthioglucose. After the onset of obesity, one month after goldthi...
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Article
Hypoglycaemia induced by antibodies to insulin receptor following a bone marrow transplantation in an immunodeficient child
Severe hypoglycaemia developed seven months after a bone marrow transplantation in a child with severe combined immunodeficiency. His serum exerted potent insulin-like activity: (a) it stimulated insulin recep...
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Chapter and Conference Paper
Insulin receptor tyrosine kinase and insulin action
Regulation of cellular metabolism and growth by insulin is the result of a series of events initiated by the interaction of the hormone with its cell surface receptors. The insulin receptor structure has been ...
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Chapter and Conference Paper
Insulin Receptor: Role of Receptor Tyrosine Kinase in Insulin Signalling and Action
Regulation of cellular metabolism and growth by insulin is the result of a series of events initiated by the interaction of the hormone with its cell surface receptors. The insulin receptor structure has been ...
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Chapter and Conference Paper
Insulin Receptor Kinase and Insulin Action
Insulin has been shown to elicit its numerous biological effects by interacting with a specific cell-surface receptor. The insulin receptor structure has been elucidated through a variety of techniques (Van Ob...
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Chapter and Conference Paper
A Preclinical Study on the Effects of Acarbose on Mice Rendered Obese with Gold Thioglucose
The effect of acarbose has been studied in mice made obese and hyperinsulinemic by gold thioglucose (GTG). One month after GTG administration, when obesity started to develop, mice were treated orally with aca...
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Article
Effect of exercise on protein turnover in muscles of lean and obese mice
The effect of work-induced hypertrophy on skeletal muscle protein metabolism was studied in lean mice and in mice rendered obese with goldthioglucose. After tenotomy of the gastrocnemius muscle, the adaptative...
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Article
Effect of work-induced hypertrophy on muscle glucose metabolism in lean and obese mice
The effect of work-induced hypertrophy (without any concomitant change in circulating parameters) on skeletal muscle metabolism was studied in lean mice and in goldthioglucose obese-mice. Soleus muscle was fun...
