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Chapter and Conference Paper
Cortical Map** of Pathological Tau Proteins in Several Neurodegenerative Disorders
One of the main features of numerous neurodegenerative disorders is the presence of specific inclusions in the cerebral cortex. In most of these disorders, these inclusions correspond to the aggregation of abn...
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Chapter
Differential Changes in Regional Brain Ganglioside and Neutral Glycosphingolipid Contents in Alzheimer’s Disease
Dementia of the Alzheimer type or Alzheimer’s disease (AD) is a chronic organic disease of the brain affecting primarily the elderly population.1 It is characterized histopathologically by the intraneuronal accum...
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Article
Biochemical map** of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement
A biochemical study was performed to quantify and map the neurodegenerating process in cortical and subcortical brain areas from a case of progressive supranuclear palsy (PSP). Our approach was based on a West...
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Article
Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain
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Article
Neuronal transformations in Alzheimer's disease
Brains of nine early and four advanced Alzheimer patients have been investigated, utilizing three approaches to specify the threshold state of Alzheimer's disease (AD). Extensive thin sectioning electron micro...
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Chapter and Conference Paper
The IMAGE Project: A Geographical Laboratory for the Integration of Multidisciplinary Data
The absence of an adequate experimental model constitutes a significant barrier to the study of Alzheimer’s disease (AD). The establishment of a population-based registry of Alzheimer cases was initiated in th...
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Article
Evidence for increased amyloid enhancing factor activity in Alzheimer brain extract
Soluble brain extracts containing 0.1 to 16 mg of protein from 3 normal human brain and 11 patients with Alzheimer's disease, Down's syndrome and other neurological disorders were assayed for amyloid enhancing...
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Chapter
Transformation of the Neurofilamentous Network Components into PHF-Like Strands and PHF Paracrystals
The threshold theory of the causation of Alzheimer’s disease (AD), as formulated by Roth et al.1 has important implications for diagnosis, clinicopathological correlation and scientific inquiry. The theory is bas...
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Chapter and Conference Paper
Pathological Changes Relevant for Seizure Generation
The type and extent of morphological changes which may be correlated with the electrophysiological phenomena characteristic of either the partial or generalized epilepsies cannot be dissociated from the molecu...
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Chapter
Cell Counts in the Nucleus Basalis of Meynert and the Supraoptic Nucleus in Alzheimer-Diseased Brains
In autopsy studies of Alzheimer’s disease (AD) cases, a profound reduction of choline acetyltransferase (ChAT) activity in cerebral cortex and hippocampus brain homogenates has been observed by several groups....
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Chapter and Conference Paper
Un registre informatisé de vaccinations pour répondre à la diversité de vaccinateurs
Au Québec, les parents ont le choix de faire immuniser leurs enfants par leur médecin de famille, leur pédiatre, ou la clinique communautaire de leur localité. Les systèmes de santé qui laissent ainsi aux util...