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  1. No Access

    Article

    CALET Observations during the First 5 Years on the ISS

    The CALorimetric Electron Telescope CALET is collecting science data on the International Space Station since October 2015 with excellent and continuous performance. Energy is measured with a deep homogeneous ...

    P. S. Marrocchesi, O. Adriani, Y. Akaike, Y. Asaoka, E. Berti… in Physics of Atomic Nuclei (2021)

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    Article

    Antimony from brake dust to the combined sewer collection system via road effluent under rainy conditions

    Abrasion of the brake lining of automobiles is one of the main antimony (Sb) sources on the road. Therefore, the road effluent possibly supplies Sb to the combined sewer collection system. However, Sb in road-...

    H. Ozaki, K. Yoshimura, Y. Asaoka, S. Hayashi in Environmental Monitoring and Assessment (2021)

  3. No Access

    Article

    CALET Results after Three Years on Orbit on the International Space Station

    The CALorimetric Electron Telescope (CALET) is an astroparticle physics experiment installed on the International Space Station since August 2015. The CALET mission was conceived to address several outstanding...

    P. Maestro, O. Adriani, Y. Akaike, Y. Asaoka, E. Berti… in Physics of Atomic Nuclei (2019)

  4. No Access

    Article

    Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation

    Epigenetic gene regulation linked to oncogenic pathways is an important focus of cancer research. KDM3A, a histone H3 lysine 9 (H3K9) demethylase, is known to have a pro-tumorigenic function. Here, we showed t...

    T Nakatsuka, K Tateishi, Y Kudo, K Yamamoto, H Nakagawa, H Fujiwara… in Oncogene (2017)

  5. Article

    Open Access

    Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression

    Sharpin (Shank-associated RH domain-interacting protein, also known as SIPL1) is a multifunctional molecule that participates in various biological settings, including nuclear factor-κB signaling activation an...

    Y Tanaka, K Tateishi, T Nakatsuka, Y Kudo, R Takahashi, K Miyabayashi… in Oncogenesis (2016)

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    Article

    Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients

    A recent study revealed that the p110α (PIK3CA), catalytic subunit of phosphatidylinositol 3-kinase (PI3K), is somatically mutated in many types of cancer. For example, PIK3CA is mutated in an estimated 35.6% of ...

    Y Tanaka, F Kanai, M Tada, Y Asaoka, B Guleng, A Jazag, M Ohta, T Ikenoue… in Oncogene (2006)

  7. No Access

    Article

    The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1

    Hepatitis B virus X protein (HBx) has many cellular functions and is a major factor in hepatitis and hepatocellular carcinoma caused by HBV infection. A proteomic approach was used to search for HBx-interactin...

    Y Tanaka, F Kanai, T Ichimura, K Tateishi, Y Asaoka, B Guleng, A Jazag, M Ohta… in Oncogene (2006)

  8. No Access

    Chapter

    Induction of 12-Lipoxygenase Expression by Epidermal Growth Factor is Mediated by Protein Kinase C in A431 Cells

    In a previous study, we demonstrated the presence of a 12-lipoxygenase enzyme in a microsomal fraction of human epidermal carcinoma A431 cells, whose activity was induced with a 10-h lag period by epidermal gr...

    W. C. Chang, Y. W. Liu, Y. Asaoka, H. Suzuki… in Eicosanoids and Other Bioactive Lipids in … (1997)

  9. No Access

    Chapter

    Lipid Messengers and Protein Kinase C for Intracellular Signalling

    Inositol phospholipid hydrolysis by phospholipase C was once thought to be the sole mechanism to produce diacyglycerol which relays information of extracellular signals to intracellular processes through activ...

    S. Nakamura, Y. Asaoka, F. Hullin… in Pharmacological Sciences: Perspectives for… (1995)