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  1. No Access

    Article

    Gene therapy for deafness

    Hearing loss is the most common sensory deficit in humans and can result from genetic, environmental or combined etiologies that prevent normal function of the cochlea, the peripheral sensory organ. Recent adv...

    D C Kohrman, Y Raphael in Gene Therapy (2013)

  2. Article

    Open Access

    BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice

    Current therapy for patients with hereditary absence of cochlear hair cells, who have severe or profound deafness, is restricted to cochlear implantation, a procedure that requires survival of the auditory ner...

    H. Fukui, H. T. Wong, L. A. Beyer, B. G. Case, D. L. Swiderski… in Scientific Reports (2012)

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  3. No Access

    Article

    Eye-head coordination in the guinea pig II. Responses to self-generated (voluntary) head movements

    Retinal image stability is essential for vision but may be degraded by head movements. The vestibulo-ocular reflex (VOR) compensates for passive perturbations of head position and is usually assumed to be the ...

    N. Shanidze, A. H. Kim, S. Loewenstein, Y. Raphael… in Experimental Brain Research (2010)

  4. No Access

    Article

    Eye–head coordination in the guinea pig I. Responses to passive whole-body rotations

    Vestibular reflexes act to stabilize the head and eyes in space during locomotion. Head stability is essential for postural control, whereas retinal image stability enhances visual acuity and may be essential ...

    N. Shanidze, A. H. Kim, Y. Raphael, W. M. King in Experimental Brain Research (2010)

  5. No Access

    Article

    Gene transfer using bovine adeno-associated virus in the guinea pig cochlea

    Gene transfer into the cells of the cochlea is useful for both research and therapy. Bovine adeno-associated virus (BAAV) is a new viral vector with potential for long-term gene expression with little or no si...

    S B Shibata, G Di Pasquale, S R Cortez, J A Chiorini, Y Raphael in Gene Therapy (2009)

  6. Article

    Cochlin Isoforms and Their Interaction with CTL2 (SLC44A2) in the Inner Ear

    Choline transporter-like protein 2 (CTL2) is a multi-transmembrane protein expressed on inner ear supporting cells that was discovered as a target of antibody-induced hearing loss. Its function is unknown. A 6...

    P. K. Kommareddi, T. S. Nair, Y. Raphael… in Journal of the Association for Research in… (2007)

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  7. No Access

    Article

    Deafness: Lack of regulation encourages hair cell growth

    Y Raphael, D M Martin in Gene Therapy (2005)

  8. No Access

    Article

    Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity

    Gentamicin administration often results in cochlear and/or vestibular hair cell loss and hearing and balance impairment. It has been demonstrated that adenovirus-mediated overexpression of glial cell line-deri...

    M Suzuki, M Yagi, JN Brown, AL Miller, JM Miller, Y Raphael in Gene Therapy (2000)

  9. No Access

    Article

    Transduction of the contralateral ear after adenovirus-mediated cochlear gene transfer

    Cochlear gene transfer is a promising new approach for inner ear therapy. Previous studies have demonstrated hair cell protection with cochlear gene transfer not only in the inoculated, but also in the uninocu...

    T Stöver, M Yagi, Y Raphael in Gene Therapy (2000)

  10. No Access

    Article

    Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear

    Acoustic overstimulation can lead to sensory cell (hair cell) loss in the auditory epithelium. Damaged hair cells in the organ of Corti (the mammalian auditory end-organ) degenerate and are replaced by non-sen...

    Y. Raphael in Journal of Neurocytology (1992)