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Article
Open AccessThe interaction of perfluoroalkyl acids and a family history of diabetes on arthritis: analyses of 2011–2018 NHANES
Whether a family history of diabetes (FHD) and exposure to perfluoroalkyl acids (PFAAs) are correlated with an increased risk of develo** arthritis remains unclear. This cross-sectional study was conducted t...
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Article
Open AccessA prognostic nomogram for predicting recurrence-free survival of stage I–III colon cancer based on immune-infiltrating Treg-related genes
A high postoperative recurrence rate seriously impedes colon cancer (CC) patients from achieving long-term survival. Here, we aimed to develop a Treg-related classifier that can help predict recurrence-free su...
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Article
Open AccessResveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway
Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery embolism, and other diseases and can lead to local intestinal n...
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Article
Open AccessActivating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome
Peritoneal adhesions (PAs) are a serious complication of abdominal surgery and negatively affect the quality of life of millions of people worldwide. However, a clear molecular mechanism and a standard therape...
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Chapter and Conference Paper
A Novel Pre-processing Method for Enhancing Classification Over Sensor Data Streams Using Subspace Probability Detection
The rapid development of the Internet of Things has led to the widespread use of sensors in everyday life. Large amounts of data through sensing devices are collected. The data quantity is massive, but most of...
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Article
Open AccessHigh glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer
Diabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) is an important transcription factor invol...
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Article
Open AccessInhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions
Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic duc...
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Article
Open AccessLipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is cata...
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Article
Resveratrol inhibits hepatocellular carcinoma progression driven by hepatic stellate cells by targeting Gli-1
Hepatocellular carcinoma (HCC) is characterized by hypervascularity. Hepatic stellate cells (HSCs) play very important roles in HCC malignant progression, as these cells facilitate HCC tumorigenesis and metast...
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Article
Gli-1 is crucial for hypoxia-induced epithelial-mesenchymal transition and invasion of breast cancer
Hypoxia can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT) and invasion of cancer cells. However, their mechanisms remain unclear. The objective of this study was to evaluate ...
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Article
The SDF-1/CXCR4 axis induces epithelial–mesenchymal transition in hepatocellular carcinoma
Hepatic stellate cells play a role in the migration process of hepatocellular carcinoma cells. Here, we address the role of the stromal-derived factor-1/CXC chemokine receptor 4 (SDF-1/CXCR4) axis on hepatocel...
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Article
Open AccessHedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT) and invasion. However, it is not quite clear how hypoxia may contribute to these events. Here we investigate the role of Hedgehog...
