210 Result(s)

Article

A novel ACE inhibitory peptide from Pelodiscus sinensis Wiegmann meat water-soluble protein hydrolysate

Pelodiscus sinensis meat is a nutritional food and tonic with angiotensin-converting enzyme (ACE) inhibitory activities. To identify the bioactive substances responsible, several bioinformatics methods were integ...

Pengying Liao, Huayu Liu, Xueqin Sun, **nrui Zhang, Miao Zhang, **anyou Wang… in Amino Acids (2024)

Article

Structural basis for human Ca_v3.2 inhibition by selective antagonists

The Ca_v3.2 subtype of T-type calcium channels has been targeted for develo** analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM structures of Ca_v3.2 alone and in compl...

Jian Huang, **ao Fan, Xueqin **, Chen Lyu, Qinmeng Guo, Tao Liu… in Cell Research (2024)

Article

Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP

Ensartinib, an approved ALK inhibitor, is used as a first-line therapy for advanced ALK-positive non-small cell lung cancer in China. However, the hepatotoxicity of ensartinib seriously limits its clinical app...

Wentong Wu, **** Li, Yiming Yin, Yourong Zhou… in Cell Biology and Toxicology (2024)

Article

Recurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth

The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...

Fei Tang, Zhonghua Wang, Yan Sun, Linlin Fan, Yun Yang, Xueqin Guo… in BMC Genomics (2024)

Article

Identification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid-lactation of dairy cattle

Characterization of regulatory variants (e.g., gene expression quantitative trait loci, eQTL; gene splicing QTL, sQTL) is crucial for biologically interpreting molecular mechanisms underlying loci associated w...

Yongjie Tang, **ning Zhang, Wenlong Li, Xueqin Liu, Siqian Chen, Siyuan Mi… in BMC Genomics (2024)

Article

Genome-wide identification and expression pattern analysis of the Aux/IAA (auxin/indole-3-acetic acid) gene family in alfalfa (Medicago sativa) and the potential functions under drought stress

Auxin/induced-3-acetic acid (Aux/IAA) is an important plant hormone that affects plant growth and resistance to abiotic stresses. Drought stress is a vital factor in reducing plant biomass yield and production...

**qing Zhang, Shuxia Li, Xueqin Gao, Yaling Liu, BingZhe Fu in BMC Genomics (2024)

Article

Identification of genomic characteristics and selective signals in Guizhou black goat

Guizhou black goat is one of the indigenous black goat breeds in the southwest region of Guizhou, China, which is an ordinary goat for mutton production. They are characterized by moderate body size, black coa...

Lingle Chang, Yundi Zheng, Sheng Li, ** Niu, Shihui Huang, Qingmeng Long… in BMC Genomics (2024)

Article

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and developmen...

Jie Zhao, Chen Yao, Yongqin Qin, Hanyong Zhu, Hui Guo, Binbin Ji… in Cell Death & Disease (2024)

Article

Integrating genomic sequencing resources: an innovative perspective on recycling with universal Angiosperms353 probe sets

Sequencing strategies have continually advanced, with high-throughput sequencing (HTS) technologies emerging as pivotal tools in plant phylogenomics. As a standard form of target capture sequencing, hybridizat...

Xueqin Wang, Tao **ong, Yiying Wang, **nru Zhang, Miao Sun in Horticulture Advances (2024)

Article

Genome-wide identification of B-box zinc finger (BBX) gene family in Medicago sativa and their roles in abiotic stress responses

B-box (BBX) family is a class of zinc finger transcription factors (TFs) that play essential roles in regulating plant growth, development, as well as abiotic stress. However, no systematic analysis of BBX genes ...

Shuxia Li, Shuaiqi Guo, Xueqin Gao, **aotong Wang, Yaling Liu, **g Wang… in BMC Genomics (2024)

Article

Retraction Note: Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7

Binbin Yu, Kailiu Wu, Xu Wang, Jianjun Zhang, Lizhen Wang… in Cell Death & Disease (2024)

Article

Genome-wide association study reveals serovar-associated genetic loci in Riemerella anatipestifer

The disease caused by Riemerella anatipestifer (R. anatipestifer, RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as the O-antigen and capsular...

Zhishuang Yang, Xueqin Yang, Mingshu Wang, Renyong Jia, Shun Chen… in BMC Genomics (2024)

Article

Publisher Correction: Interim survival analysis of the randomized phase III GEMSTONE-302 trial: sugemalimab or placebo plus chemotherapy as first-line treatment for metastatic NSCLC

Caicun Zhou, Zi** Wang, Meili Sun, Lejie Cao, Zhiyong Ma, Rong Wu… in Nature Cancer (2024)