9 Result(s)
within
Wuyuan **e
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessReaction engineering blocks ether cleavage for synthesizing chiral cyclic hemiacetals catalyzed by unspecific peroxygenase
Hemiacetal compounds are valuable building blocks in synthetic chemistry, but their enzymatic synthesis is limited and often hindered by the instability of hemiacetals in aqueous environments. Here, we show th...
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Article
Open AccessRational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles
Chiral heterocyclic compounds are needed for important medicinal applications. We report an in silico strategy for the biocatalytic synthesis of chiral N- and O-heterocycles via Baldwin cyclization modes of hydro...
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Article
Open AccessHuman intelectin-1 (ITLN1) genetic variation and intestinal expression
Intelectins are ancient carbohydrate binding proteins, spanning chordate evolution and implicated in multiple human diseases. Previous GWAS have linked SNPs in ITLN1 (also known as omentin) with susceptibility to...
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Open AccessPhotobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids
En route to a bio-based chemical industry, the conversion of fatty acids into building blocks is of particular interest. Enzymatic routes, occurring under mild conditions and excelling by intrinsic selectivity...
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Open AccessA single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17
Recent data highlight the presence, in HIV-1-seropositive patients with lymphoma, of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagenesis. We investigated the m...
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Open AccessCellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17
The human immune deficiency virus type 1 (HIV-1) matrix protein p17 (p17), although devoid of a signal sequence, is released by infected cells and detected in blood and in different organs and tissues even in ...
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Open AccessMolecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240
Antibody-dependent cell-mediated cytotoxicity (ADCC) by non-neutralizing antibodies (nnAbs) specific to the HIV envelope (Env) glycoproteins present at the surface of virus sensitized or infected cells plays a...
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Open AccessThermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins
Human defensins are innate immune defense peptides with a remarkably broad repertoire of anti-pathogen activities. In addition to modulating immune response, inflammation and angiogenesis, disintegrating bacte...
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Open AccessSurrounding Sensitive Electronic Properties of Bi2Te3 Nanoplates—Potential Sensing Applications of Topological Insulators
Significant efforts have been paid to exploring the fundamental properties of topological insulators (TIs) in recent years. However, the investigation of TIs as functional materials for practical device applic...
